Talk:2012 Group 4 Project

From CellBiology

Group Assessment Criteria 2012

  • The key points relating to the topic that your group was allocated are clearly described.
  • The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  • Content is correctly cited and referenced.
  • The wiki has an element of teaching at a peer level using the student’s own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  • Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  • Relates the topics and content of the Wiki entry to learning aims of cell biology.
  • Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer’s wiki.
  • Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  • The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  • Develops and edits the wiki entries in accordance with this sites wiki guidelines.


  • Z3287603 - 153
  • Z3289642 - 69
  • Z3330968 - 1
  • Z3290558 - 130

Total edits - 353

Project page has been accessed 1,700 times.

Positive Negative
  • Fair structure to project.
  • Good research on topic.
  • History section.
  • Some good figures.
  • Project structure and layout could have been improved.
  • Student image quality and supporting information.


  • Z3287603 - 4 figures including Wikipedia image, files lack full associated information.
  • Z3289642 - 4 figures including student drawn images, these drawn images are poor quality and have no associated information describing elements in cartoons.
  • Z3330968 - 0 figures.
  • Z3290558 - 2 figures, including student drawn image.

Notch signaling: a simple pathway becomes complex[15] This text is linked to nothing and the Nature ref should have been included in the associated student drawn figures.

--Mark Hill 11:38, 4 April 2012 (EST) As of Wed 4th April (week 5) other than the requested individual assessment references there is nothing on either your project page (other than the template sub-headings I provided) or discussion page (reference to Facebook page for work allocation) that indicates that any work has been carried out on this project. I am happy for you to use other media in your discussions, but remember my assessment will be based upon what appears on your Project/Discussion page. I remind you of the assessment criteria and my expectation of ongoing demonstrable contributions.

--Z3287603 15:11, 22 March 2012 (EST)


hey hun this article talks about about abnormality, i came across it have a look Functional role of Notchsignaling in the developing and postnatal heart --Z3289642 17:39, 23 May 2012 (EST)

Initially with my section I was going to do pancreatic cancer because I wrote about notch in pancreas development HOWEVER most of the normal function passage included the abnormalities when Notch receptors are not present so do you guys have any other suggestions as to what we should include in abnormalities? Focus on other cancers?--Z3287603 17:11, 23 May 2012 (EST)

Just checked them and i think it looks fine :) I just bolded the title of the references though so it follows the same pattern as the other references. and the table does look great! nice work! --Z3290558 16:10, 23 May 2012 (EST)

Guys I'm having trouble with my references!! :( Most of the references I used for the first section of Abnormal Function are not from pubmed, I used sirius and obtained the references from that. I referenced them best to my knowledge, could you guys please check over 13-15 for me?--Z3287603 15:33, 23 May 2012 (EST)

thanks! yes omg im struggling with references for the table at the moment. haha when i work them out they shall have references too!--Z3289642 15:24, 23 May 2012 (EST)

Just a another thing, Rbpj is not a typo as this is referring to the transgenic mice that was used in the experiment, recall the lab on knock-out techniques, Rbjp is the certain gene they were referring to. BTW are they any references for the proteins section? We might need to mention some references in the content in the table. By the way I shifted the image from the proteins/receptor section to the pathway section as the image reflects the pathway better and more relevant. The table looks AWESOME! good job :) FInally our page is looking spectacular with all these lovely colours. --Z3287603 14:33, 23 May 2012 (EST)

you arent being difficult chill weve all had assessments haha we all understand. okay so some of the links are

Notch signaling

Lecture on the Pathway

Notch signaling and inherited disease syndromes

Notch Signaling, Brain Development, and Human Disease

ill put the rest up later

--Z3289642 14:30, 23 May 2012 (EST)

ALSO " Also another thing: in 'notch in pancreatic development' what is the Rbpjand that you're talking about? or is that a typo?? and was it intentional that you spoke about rbpi and rbpj?? i'm left a bit confused :S" HAHAHA yes it is a typo, I have my abnormal function pretty much finished and editing on word as we speak. I also have another assignment due but will def def finish everything by tonight. So sorry for being difficult guys. --Z3287603 13:17, 23 May 2012 (EST)

Hey guys, So sorry I haven't been communicating as much but I have a lot going on at the moment. I think in terms of referencing a review article, use the PMID and then add a side note and say it's a review article? I am not too sure whether this is the correct way of referencing it. I believe Mark gave us a sheet on the certain short cuts but I don't know where I placed it. I'll have a look at it now and get back to you, until then maybe follow what I said. --Z3287603 13:15, 23 May 2012 (EST)

okay hun last night i got some amazing websites and some more informative sites and articles. im so excited to finish this. im uploading the photo images now we can have way more than one student-drawn image right? ill do those glossary words as well. ive got so much information right now i need to get it all out!

--Z3289642 12:32, 23 May 2012 (EST)

I looked through our project quickly and picked out the words that I think needs to be filled in the glossary. (remember we're targeting for those who have no scientific background)


  • polypeptide
  • proteolytic
  • nucleus
  • bipartite

Proteins and receptors:

  • epidermal
  • transmembrane protein
  • globular protein

Normal function:

  • apoptosis
  • multipotent progenitors
  • ventricle
  • pericyte
  • exocrine
  • endocrine
  • nephron
  • podocyte

Also another thing: in 'notch in pancreatic development' what is the Rbpjand that you're talking about? or is that a typo?? and was it intentional that you spoke about rbpi and rbpj?? i'm left a bit confused :S

lets fix this up and finish adding all our info thats due!! we have one day left!!! lets do this!

--Z3290558 12:06, 23 May 2012 (EST)

how do we reference review articles? --Z3290558 13:34, 22 May 2012 (EST)

Hey girls, do you think if we have time after we fix up our parts, under the abnormal function part we could also include a 'possible inherited diseases' section which would have the diseases that are caused from abnormalities formed? I can look after that sub-section if you want to include it. Let me know!

And also, I'm happy to draw a student drawn image for the introduction of a Drosophilia fly by hand. I'll upload it soon.

--Z3290558 18:07, 21 May 2012 (EST)

Discussion based on peer review

Things that need to be improved:

  • Introduction - larger + more informative and more linked
  • History - find out whats happening from 1930s-1978 and 1995-onwards
  • Pathways + Protein receptors- upload student images and table contents
  • Normal function - perfect obvs.
  • Abnormal function - more information + diagram
  • Videos - tie it in with proteins and receptors plus add hyperlinks
  • Research - needs A LOT more information, need to get rid of PMID we need to hyperlink it to the actual page. more words and more references

YAY lets do this.

--Z3289642 15:38, 17 May 2012 (EST) and --Z3287603 15:39, 17 May 2012 (EST)



  • Clear cut and straight to the point


  • a bit too brief

Pathway, Proteins and Receptors

  • I thought the pathway was well explained, but more detailed description would be better. Also, proteins and receptors might be better as a subheading under pathways? The image is good, but maybe should include a brief description

Normal Function

  • This section is well researched, clear layout and the flow chart helped in explaining about the role of Notch in CNS. Each sub section has a nice intro and, brief detailing and closing, overall i thought this section was good.

Abnormal Function?

Further Research

  • Lack of description on each article, even a brief intro on what they are researching on would be good

  • The Introduction is succinct and well structured. It also makes reference to topics that are going to be covered in the project. There is a remark about specific ligands and their families, and it seems this piece of information is missing a citation. Maybe the addition of an image to this section would enhance the appeal.
  • The History section is set out very neatly and is easy to follow. citations have also been appropriately attached.
  • The Pathway section is probably the most important element of the project. Unfortunately it feels that this section is still incomplete. The language used is quite difficult to follow, and the author has made no attempt to explain the jargon. Furthermore, there is only one citation made, so it seems that many citations are missing. Because of the elaborate nature of this section of the project, it would be better to incorporate the use of bullets to organise the information, hence the text would be easier to follow.
  • The section for Proteins and Receptors has been done very well. The information is organised very neatly incorporating bullets and subheadings. The image used is very useful and entirely relevant to the topic. A related video has been recommended, with is an impressive addition, however it would be easier for the reader if a hyperlink was made within the same section of the project, rather than mention the video is located under another section. In addition it would be a pleasant addition if you would incorporate further readings for specific proteins or receptors.
  • The section for Normal function is very impressive. The information provided is extremely relevant, and has been set out neatly. Subheadings allowed for good organisation of the various roles of Notch in various tissues. The image of the flow chart is a great summary of the information, however this image needs to have a copyright notice. Furthermore, the information has been well cited.
  • Under the heading for External links, the subheading ‘Further research’ should probably be done under its own separate heading. Also the author should make reference to further readings, rather than just videos.
  • Glossary is on the right path, but should incorporate more terms.
  • References have been done correctly, but again there should be more present.

There is no title to show what your page is about! and thought it was relatively short page

  • Introduction: too short and lack of information
  • History: like the table and the content but you should find more information...
  • Pathway: too brief and lack of image to help understand the reader
  • Proteins and Receptors: like the overal lay out and t but...) but it is not referenced.
  • Normal Fuction: love the orientation, it was easy to read and understand!

--Z3291200 02:46, 17 May 2012 (EST)

•Introduction: The introduction is too short. It talked about what are the types of notch, its ligands and where they can be found but it failed to mention what is Notch and what does it do. I think giving a simple description of what Notch is and what does it do is the purpose of having an introduction. Despite of this, the section is well referenced.

•History: The table format of this section makes it easy to read. I think this section could be researched more. I tried searching Notch on pubmed and hundreds of journal articles were found, therefore, there are more history that you can put in this section.

•Pathway: This section is too short. Very little information can be read and it lacks depth. Having an image would help your readers follow what you are discussing.

•Protein and Receptors: This section looks good although not referenced. I suggest for the part "See video under external link for further understanding." You can already link the video here rather than having to scroll all the way down to watch the video. Also, there are no references given in this section.

•Normal Function: This is the best section of your project. It is well referenced and gives a simple and easy to read understanding about the topic.

•External Link: It's good to have this at the bottom but also link it will be better if it was linked to the section that it relates to.

•Further research: The further research section showed little research. Only titles of articles were given and their corresponding links. This could be improved by giving a brief description of each current research linked.


  • Little lacking in info.
  • Could use a good picture.


  • Again, little lacking in information.
  • Good use of a table.


  • As this is the main topic of the study, this needs the most attention.
  • NEEDS an image to help show the pathway.
  • Could use steps to show order and help readability.

Proteins and Receptors

  • Don't know why the videos and such are referred in here. Should be in pathway.
  • Little more written info on each of the major proteins.
  • Image needs a copyright notice.

Normal Function

  • Good section, well referenced and plenty of info and good use of an image.
  • Image needs reference and copyright notice.
  • Could maybe link each subsection together at the end with a small paragraph.

External links

  • This section should come after Further Research.
  • Further Research needs more information.


  • Looks good, but there should probably be more words in there from your report.


  • Properly referenced, just need more done to it.

-Introduction: I thought that the introduction was very short, it lacked a good outline due to this.

-History: I thought that the table was well presented. Easy to read and understand. I just thought there could have been more information throughout it.

-Pathway: I thought that this section was very brief. This made some of it hard to understand. Also, a flow chart would have helped.

-Proteins: I thought that this section was really good. It was easy to understand

-Function: I thought that there was a lot of good research here and it was well presented. This was good.

-Further Research: I thought this section could have been better. It didn’t really give a lot of examples of anything.

- I thought overall it was very short and not well executed. They are on the right path, it just needs to be elaborated.


Very brief and easy to understand, but seems too short maybe adding a few more subheading to the project and adding some info to the introduction help to make the whole project better.


History is done and it well referenced but again it seems too short with big gaps between each important discovery. More research should help fill up some of the gaps in this section.


Too short, information is scatter and don’t follow a logical order, this because not enough research was done.

Proteins and receptors

This section is fairly well organised but not referenced. The picture used is not referenced too.

Normal function

This section is done very well, well organised and good use of picture and well referenced.

There is no title!

  • Introduction: Very brief, addition of image if possible?
  • History: Table is fine, though did nothing happen between 1930-78? Feels like more info could be added.
  • Pathway: Is there such thing as notch 2 and 3? Concise information, any images to support?
  • Proteins and Receptors: Well done, very appealing with all the formatting. Good work!
  • Function: A lot of information, but set out neatly, which make it much easier to read. Enjoyed it.
  • External links: the “Further Research” section could have some text in regards to the future research besides just having a link.
  • Glossary: Kind of short, but mostly well done.
  • References: Good work, looks great!

Overall the page seems a little short. It’s looking great so far, but I think it just lacks a bit more information and possibly an image in the introduction.

  • Introduction: Easy to understand and a good outline for the rest of the page.
  • History: The table is well designed. The information is simple and well explained which shows a good understanding of the content (as opposed to paraphrasing complicated text). It is important to include the full name of the researchers (eg. Who is 'Lewis'?) and where possible links to the research articles. Surely there have been further discoveries since 1995.
  • Pathway: This section is well explained and I liked the summary paragraph. A flowchart would be ideal here; this would be a good place for the hand-drawn diagram.
  • Proteins and Receptors: I like the simple layout of the text, however more information is required. Perhaps set up a table to compare the structure and functions of each component, and highlight their importance to the pathway. The picture is really good, however I feel that it is more relevant for the 'Pathway' section. References are needed!
  • Normal Function: I don't feel that the specific role of Notch in CNS & cardiac development was well described. You have a really great flowchart illustrating the role in CNS development, so perhaps you should explain what is happening in that picture. This was done better in the role of Notch in kidney and pancreatic development, where you went into detail of what the Notch pathway is responsible for and the background information on how these discoveries were made.
  • Overall Impression: I really enjoyed reading the information on this page. The explanations are clearly written in your own words and are easy to follow and understand. The information is well formatted into subheadings and tables which makes it easy to navigate around key points. That being said, there is a lot of information missing and most sections need to be expanded on (however this has already been pointed out by many others).

what was done well;

  • Normal Function section was very well written. I could understand the different roles of Notch in different tissues very easily. It gave a wide range of functions and picture is quite relevent to Notch in the CNS. This section had nice layout with the subheadings.
  • correct referencing and citations used
  • enjoyed the video

what needs Improving:

  • Your page seems rather short and many of your sections need expanding. In you intro, can you give an overview of everything you're going to talk about? The future research section doesn't appaer to have information - just the references to some literature.
  • You need a diagram for your Pathway. I find it hard to understand the text.
  • history section doesn't explain what happpened between the 30s and 1970s.

The "normal function" section is especially well done. I am impressed by the clear layout, referencing, and relevance in the picture. Together it facilitates in drawing me in and engaging my interest. I'd like to point out, however, you're missing the reference for the figure.

Frankly, the rest of the page gives the impression of, at best, half-heartedness. I won't comment on "abnormal function", which currently does not exist. For example, the introduction sounds like an essay intro and not a wiki. This may have been an unintentional error arising from the unfamiliarity of how wiki intros are set out, and if that's the case, I suggest looking up some examples of introductions of cell signalling pathways on Wikipedia. Another example is "history". It seems awfully short to me… surely more has taken place in the way of scientific advances for notch signalling from 1917 till 2012? Like what about the gap between 1930-1978 and also 1980-1995? Additionally, I think the image linked under "proteins and receptors" would be more appropriate under the "pathways" section. Instead, images depicting the gene sequences or even the 3D crystal structures should be included under "proteins and receptors".

Just another suggestion is beginning your wiki page with the name of the signalling pathway you are talking about. That way it's clear from the beginning what you are writing about.

  • Pros
    • Content correctly cited and referenced
    • Well formatted table in “History” section; makes information easily readable
    • Good use of dot points and subheadings in “Proteins and Receptors” section
    • Subheadings in “Normal Function” section made information easier to follow
  • Cons
    • “History” section lacking a bit of information and research (only 3 sources referenced)
    • “Pathway” section hard to follow (maybe include flow diagrams of signalling pathway? Possibly student-drawn?)
    • Images under “Proteins and Receptors” and “Normal Function” sections lack copyright information
    • Greater breadth of research needs to be conducted, reference list is not very comprehensive
    • “Normal Function” section needs proof-reading (For example, the opening three lines read: “Notch signalling pathway plays a vital role in metazoan development. Notch protein activates a signalling pathway that controls the expression of genes that are responsible for cell division, growth, migration and apoptosis. Utilization of the Notch signalling pathway determines the fate of cells in the embryonic phase.”). These sentences sound more like dot points; add “The” to the start of them or format them in dot point form.
    • No abnormal function/implications in disease section
    • No student-drawn image

  • There is no large title saying NOTCH signalling- it should be added so people know what the page is about before reading.
  • Intro is short, thats fine so long as you expand on what is said throughout the project. History is also short, i heard this signalling pathways is fairly recent and difficult to study, but maybe just a few more points will make it more comprehensive- it seems like its all based on Morgan and the fly. is there nothing else about the signalling or abnormal diseases which relate to notch signalling that can be added to your table.
  • Image of Notch Signaling Network , has no copyright info attached!
  • surely there is more known about the Protein and receptor section. I understand you don't want too much information that people don't want to read, but i think your page is on the other side of the spectrum, with not enough information in all sections (apart from normal function- which is detailed, but still easily read, contains a picture, would be nice to see a few more)
  • Videos are a good addition but i don't think they make up for the lack of effort in most sections.
  • Futher research; seems like someone just pasted a few pubmed no. in this section. at least write a sentence or two about what the article is hoping to discover etc.



  • good table and pictures
  • proteins involved was clear and easy to read.
  • there was a balance of writing and pictures in protein and receptor & normal func. section
  • normal function section was good, clear, good layout & info.
  • video links great for those who want further info


  • some sections were lacking more in depth info/pics when compared to other sections
  • an overall short webpage/assignment.

Possible/needed improvements:

  • what is the involvement/function of modifier proteins? More depth in their involvement ,structure of the protein if possible would be good.
  • abnormal function heading- to show a comparison of when it works and when it doesn’t.
  • a complete glossary
  • a consistent overall layout to make the whole page appealing to readers rather than some sections over others.
  • history table seems incomplete- did anything happen between 1930s-1978? 40 years unaccounted for unless nothing happened

First of all, please put down your signalling pathway as your heading. All that I can see now is the introduction - only by reading your text it becomes clear which signalling pathway you have chosen to discuss.

The introduction does not provide me with too much information as to what 'notch signalling' is. In your introduction you are supposed to give us a general overview of what you will be covering in the other sections. Most important would be to briefly mention the normal function, not solely the organs which they target. Because I did not get this information from your introduction I had a quick look at wikipedia. Now please be careful with your information! The first few sentences from the wikipedia page were very similar to what you wrote. When I looked at the reference in wikipedia and the reference you provided me with I could see that they were the same! To me this seems like you simply rearranged wikipedia text and copied their reference. I would advise you to re-write your introduction. Use wikipedia as a guideline only and give us a general (but not too general) overview of what is coming.

History looks good and is well-presented in the table. Please provide some more recent discoveries to it - I am sure some research has been done on notch signalling between 1995 and today.

The pathway sections has some good information to it, however it might make it more understandable if you put this in dotpoint form. An image/student-drawn image would also be helpful here.

It is nice and clear which proteins and receptors are involved. I did notice that there are 3 links which 'do not exist'. The picture caught my eye, which is positive. Do make sure you have the copyright statement provided.

Normal function was very expansive and had a good layout with the use of subheadings. It seems like a lot of research has been done on this section and the majority of your references are indeed listed here. When it comes to the picture, please provide us with the correct information - title and description, reference, copyright statement, etc.

Building upon function you could now discuss abnormal function, current research etc. This has not been provided yet.

It seems like you made a good attempt to start the glossary, however you could probably expand this a little. Similarly with your references, you could use a wider range of sources to get a more holistic idea of what is involved (normal/abnormal function etc). The references you do have seem to be cited correctly.

I know that it has already been mentioned, but it is very important that you have a heading for your page.

The introduction seems good and succinct. A picture would be nice at the top of the page.

Using a table for the history is a great idea, but it seems rather to simplistic and incomplete. However, the referencing for the information within the table is good.

The information about the pathway is really informative and detailed. Diagrams and labelled images would be great to explain it further.

Protein receptors, Normal function and Glossary had very good information, and the use of subheadings made everything so much more organised, and easy to follow. However, I realised a number of the links did not work, and I was not quite sure as to what the problem was, something worth figuring out.

The images were did attract my eyes, and did aid me in understanding a number of the concepts.

However, what I failed to find was information about current/future research.

References seems to be correct, and overall the information is quite detailed.

Having said this, the page probably needs more expanding, as the information seems quite limited.

  • The introduction is short, however it appears to lead that the rest of the page will provide all the information – perhaps some brief generalized info here would be good.
  • The history is formatted well, however again it appears to be too brief – this could simply be because there is not much history on notch signaling but I am unsure
  • There could be more information/elaboration in the pathway section, and there appears to be a distinct lack of citations in this section as well.
  • Again the proteins and receptors section seems fairly unfinished, esp. with the inclusion of the dead internal links. The sections also need to be expanded upon past simple dotpoints as it provides generic and basic information, but not much beyond that. There is also a lack of citations in this section.
  • The normal function section appears very well done, with an appropriate use of subheadings to differentiate the information given, a helpful image as well as a decent amount of citation.
  • The further research section is clearly unfinished, and so not much comment can be given here.

Well researched, however some sections do not appear to be referenced, such as the ‘Protein and Receptors’ section and some of the ‘Pathway’ section. The page needs a title to make it clear what the topic is. Headings are placed in a ‘flowing’ order and the use of subheadings helps to break up large chunks of text. Perhaps more sections could be added, for example abnormal function? The videos are an effective way of engaging the audience and ‘teaching’ them, as the marking criteria for this project require.

  • Introduction is well written but very brief. Perhaps you could mention that it is a signalling pathway important in cell to cell communication here and expand on that a bit and provide a picture (such as the structure of the ligand binding region on the NOTCH receptor) to make it more appealing to the reader.
  • I like the formatting of the history section. The use of a coloured table makes it very attractive to the reader. However the information in this section is very brief and does not provide a thorough representation across the decades since its discovery. You could provide information on current research like you have at the end of your assignment as it will indicate what is currently being done in this field.
  • An image could help readers understand the pathway section, however the information presented here is well written and synthesised nicely.
  • I really enjoyed both the Proteins and receptors and Normal functions sections. The information was well written and the subheadings helped unclutter the information. However there were no references for the Proteins and Receptors section. Also the image in the protein and receptors section does not have the copyright info pasted in, just a reference.
  • The future research section could be improved a brief description of what is being investigated in each study mentioned.
  • The external links were very helpful and I enjoyed your video. Additionally, a student drawn image still needs to be uploaded. One group provided external links in the text to the definitions of the words listed in the glossary, you could use this idea also. Finally, you still need to add the title of your page.

  • Introduction: The paragraph is very short however the content is concise and simple – it’s good to see you have indicated an outline of what you’re going to discuss. Perhaps you could add an image to make this section more appealing.
  • History: I think more research needs to be conducted on the history of Notch signalling to add more entries to the timeline – the timeline is not complete at the moment. The existing entries you have are well summarised and referenced. I also like the colour scheme of the table.
  • Pathway: The information in this section has been synthesised and presented very well – however I think it could improved by altering the structure to a numbered list or bullet point form with an accompanying student drawn image or diagram. I also think more referencing needs to go in this section.
  • Proteins and receptors: You’ve made a great start with this section but it’s very general at the moment. I suggest having a table format or diagram to explain the different proteins and receptors, and their respective properties.
  • Normal function: There is evidence of excellent research and synthesis in this section with the use of subheadings complimenting the information. I think you could expand more on the role of Notch signalling in the CNS and perhaps make reference to the diagram.
  • External links: The use of videos is a great idea. I suggest adding external links to current labs who are investigating Notch signalling. I don’t think future research belongs here – have it as a new section and make sure you explain the content in the articles you’ve listed.

As a whole, good effort! The page is visually appealing most of the time and has generally been structured well. All that’s left to improve is the content which is incomplete in some sections. Don’t forget to add a section about abnormal function and current research! Great work and good luck!

You need to put up a title heading on the page.

The introduction is nice and brief.

Your use of colour in the history table is very eye catching and not straining on the eyes so it is very inviting.

The actual pathway is easy to understand but it would be good if you specified which notch pathway it is.

The normal functioning part is the most well done...enough info and nice use of headings.

Also the use of videos is also ingenious to explain the pathway.

In the future research u should really explain what and how the research is being done and the benefits.

Don't forget to put a self made drawing on the page.

First of all, you should start your page with a headline: What is your theme? After reading the introduction, I have still no idea about what you are doing. In the History part you could use some pictures to illustrate your page. All in all, I really like your page. It is structured and well written.

The introduction seems to be a little bit short, thus I recommend you elaborate a bit more on the overall topic. You might also want to include the title of the pathway you are doing so that it is more obvious to readers what you will be discussing. The history section lacks variety in terms of referencing, and could include a few more important dates, but the table is visually pleasing. The pathway is detailed, however, it could be coupled with an image so that it is a little clearer to readers. Actually, the nice image you have included for your section on proteins and receptors (which was a good overview but could be a bit more detailed) should be in the pathway section. However, the image is lacking copyright information. The section on normal function is well-explained, and I like how it is formatted because it makes it easier to read. The addition of the picture makes things easier to visualize. The further research section is definitely incomplete, but I am certain you are aware of this. The glossary seems fine, but it will probably be longer once the project is finished. Overall, this project requires more work, as well as a student image. Lastly, having additional links in one section is fine, but if the links are mentioned earlier in the project, it is best to include them in that section, rather than write "See video under external link for further understanding".

The wiki currently is quite good, it highlights the role of the Notch Signaling Pathway. Some small areas to improve can include:

  1. An individual title. I think it was just overlooked but a main heading ‘Notch Signaling Pathway’ tells the reader exactly what the page is about. Saving them searching for whether they are on the correct page or not.
  2. As I advised before to another group. Try to utilise the introduction a bit more. It is strong way to give a good first impression on a reader and captivate their attention. There is a fine line between too much information in an introduction but other groups have managed to find it.
  3. In some sections, assumed knowledge is a little high. I like the way in which the information in condensed, eliminating big slabs of writing, but be careful that some sections need a little more explanation. Others go into some depth that could be left out. This could help in keeping the size nice and condensed at the same time.
  4. It also appears to be a bit short in size but I don’t feel it is lacking content, possible just some filler to give the page some size.

Overall, I believe the wiki is strong, very good portrayal of the pathway, research is very well done given the content, and layout is good so far. With some small adjustments I think it will become a very good and informative page for researchers to begin.

Group 4

• Not all key points are described or present eg abnormal functioning. More detail is needed on proteins and receptors and history and future research need more body

• Detail of normal functioning must be commended- if the entire project delved into the same level of detail as the normal functioning section does, then it would be comprehensive to say the least.

• Inclusion of relevant and interesting videos is an absolute winner idea but more images and diagrams are needed

• More information is the key. This will come good if more research articles are identified and used- this will also lead to improvement of your glossary and reference list. Remember that the length of your reference list is usually a good indicator as to how detailed and deep your research has been, proving you didn’t find one article and copy all its good points

• The evidence of the capability to conduct in depth research and information gathering is evident, so it just seems that time is the key- give it the required time and the project will come together


-external links are relevant and useful

- normal function section is excellent. well-described and interesting plus good layout

- pathway, proteins and receptors sections could be expanded a little more and organised hopefully like the normal function section

- history section could be expanded a bit with other related significant events

- more images required including student drawn

Group 4 Feedback:

The information given seems to be good, however it lacks a bit more information and elaboration, specifically in the introduction. The information provided on the Normal functioning seems to be well elaborated and researched. However, there needs to be a show of abnormal functioning on the pathological level to allow for a compare and contrast of the project. The use of videos seems to be a great idea and is well integrated within the assessment. Self made drawing on the page is also needed in the near future and further research and referencing is recommended to allow for greater expansion on the information at hand. Overall, this assessment seems to be going in the right direction.

Group Discussion:

References to use later: Artavanis-Tsakonas, S. et. al.(1999) Notch signaling: cell fate control and signal integration in development. Science. PMID: 10221902

Das, I. et. al. (2004) Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function. J. Biol. Chem. PMID: 15123653

Dontu, G. et. al. (2004) Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res. PMID: 15535842

LaVoie, M.J. and Selkoe, D.J. (2003) The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J. Biol. Chem. PMID: 12826675

Oh whoops sorry guys, I made one of the images on the right as well but we'll fix it all later. Yep right now I'm working on putting much information and expanding the glossary list as I go. Just wondering if we should put a youtube clip on notch in the external link section? --Z3287603 10:34, 10 May 2012 (EST)

okay so i found research websites as some research papers which were primarily on cancer. ill put the websites here and ill put the referenced papers down below.

GRC Conference Program on Notch Signaling in Development, Regeneration & Disease

AT Laboratory Notch Signaling Programs

Pharma Strategy Blog Notch Signaling and Brain Cancer

Breast Cancer Research - i wasnt sure how to reference this page but it actually belongs below

Nature Review Neuroscience - belongs below as well

Circulation Research - belongs below as well!

--Z3289642 09:36, 10 May 2012 (EST)

so my scanner isnt working for some unknown annoying reason but the image that i adapted it from is [this] yeah youre right about getting as much info as possible and then doing the decorations later. ive been looking for some info on research ill put some of the sites that i found up underneath under papers

--Z3289642 01:50, 10 May 2012 (EST)

Totally makes sense, I think even someone without any scientific background can figure out whats happening, great job. Really? I thought left would look better, to balance the pictures out a bit. Doesnt really matter I guess, lets just work on getting all the info up first then figure out the little decorations later. oh, and i realised you can click on the thumbnail to enlarge it if you want to and click on it again for further enlargement haha silly me. --Z3290558 21:59, 9 May 2012 (EST)

Ok following on with that, I've changed the introduction bit for the 'role of notch', have a read and let me know if it "makes sense"! For the Thumb picture go onto my section and copy the command, I reckon it'll look better on the right side of the page. Excellent that you are drawing them! How are you planning to put it up? Scanning it? --Z3287603 19:37, 9 May 2012 (EST)

in regards to the 'role in notch' subheading i dont think its hard to small or hard to read dw about that bit, its better because we are making that distinction between them. also about the proteins and receptors part have you guys figured out how to do that thumb picture thing? im drawing them at present and we can put it up tomorrow yeah?

--Z3289642 18:15, 9 May 2012 (EST)

Ok I will definitely edit that bit tonight in regards to the role. I am finding great difficulty to simplyfy the function. Would you rather me to write it as a whole paragraph and not have the sub categories? --Z3287603 08:59, 9 May 2012 (EST)

Just a random thing I noticed, do you think the 'role in notch' image under the 'Normal Function' section is too small or hard to read? --Z3290558 07:51, 9 May 2012 (EST)

Also, don't forget to be adding words to the glossary! If you had to look up the definition of the word, people visiting our page probably will have to as well! Like ' progenitors' would be a good one to put in the glossary, or even if it's slightly technical, put it in. --Z3290558 10:25, 3 May 2012 (EST)

Hey the summary would help quite a lot when it comes to the function of the signalling pathway as most of the time when the papers mention certain proteins I have no clue. I agree with you in terms of completing the introduction at the end (it just makes more sense). --Z3287603 20:34, 2 May 2012 (EST)

Yeah that sounds great. I'm actually a little confused with it as well.. Also for the introduction, we should write that part last right? Once everything is almost finished so we can write a summary and brief outline of what we will talk about in our project page right??

--Z3290558 20:15, 2 May 2012 (EST)

guys im a little confused about the proteins and receptors section? shall i just put up a small summary about each receptor and protein involved ie what it looks like, where abouts its most likely located around the body, its primary function, things like that?

--Z3289642 19:22, 2 May 2012 (EST)

hey kids, this would be really useful for research so i thought id just put it up here. Notch signaling and neurogenesis in normal and stroke brain --Z3289642 21:43, 18 April 2012 (EST)

this video is amazing. have a look if you have a bit of free time its what finally made me understand notch signaling notch signaling video

--Z3289642 17:36, 16 April 2012 (EST)

So guys i dont know if you remember but raymond actually posted this that link on notch signalling pathway when we were first deciding on which pathway to use. it turns out that it comes from the same cell signalling journal that we were using for that lab a couple of weeks ago and its literally the entire pathway sorted out. check it out and let me know what you both think?

notch signaling pathway description

--Z3289642 17:28, 16 April 2012 (EST)

Random but, do you think we're allowed to reference the textbook link you put below? --Z3290558 12:24, 13 April 2012 (EST)

Cool stuff! I'm currently looking for some stuff on the history.. its so hard.... And i hope you kept the PMID for those articles for referencing, cos it should link to the actual article itself. just like we practised in referencing in class.

Heres the link to referencing:

and btw, the textbook link is awesome! --Z3290558 10:57, 11 April 2012 (EST)

Hey guys, I've typed up some intro for my topics. I'll put it up on the main page but feel free to proof read it and let me know if I need to change anything. OH! Also check if my referencing is ok... Hope y'all have an awesome break!! --Z3287603 17:03, 10 April 2012 (EST)

Hola! I know its been difficult to find a "simpler" explanation of the notch pathway, so check out [1]. The textbook includes couple of diagrams which may help to understand the pathway. --Z3287603 20:28, 4 April 2012 (EST)

I've put the delegated roles for the research areas on our fb group page.

Check it!

--Z3290558 16:11, 29 March 2012 (EST)


Papers for Notch Signalling Pathway

1. In this article, the authors utilize the notch signalling pathway to demonstrate its importance in the development stage of Drosphila Flies. They indicate that a single mutation in notch can lead to wingless Drosophila highlighting its importance in the embryonic development stage. This article may be helpful in identifying the significance of Notch signalling.


2. This review article highlights the function and structure of notch proteins. This article gives an overview of the specific proteins and its signalling pathways which is useful in our group project.


3. In this review article, the authors examine the importance notch activity in the ”development of different organisms”. This is very useful as it allows us to understand the function of the signalling pathway not only in invertebrates but also vertebrates.


4. For many years notch signalling has been associated with the fate cell differentiation during the development stage of organisms however in this study the authors indicate its importance in cell proliferation and apoptosis. This is useful as it represents a fatal role in the cell cycle and mutation in the notch signalling pathway may lead to many diseases such as cancer.


--Z3287603 21:03, 28 March 2012 (EST)

1. Yuan JS, Kousis PC, Suliman S, Visan I, Guidos CJ. Functions of notch signaling in the immune system: consensus and controversies. Annu Rev Immunol. 2010 Mar;28:343-65. PMID: 20192807


This article reviews recent advances in terms of Notch signaling as well as tries to clearly identify Notch functions within immunological processes. It is useful in terms of getting an overview into the history of the gene as well as gaining more of an understanding into the actual pathway itself and its normal function.

2. Liu J, Sato C, Cerletti M, Wagers A. Notch signaling in the regulation of stem cell self-renewal and differentiation. Curr Top Dev Biol. 2010;92:367-409. PMID: 20816402


This article reviews notch signaling pathways at multiple stages of organismal development. It would be useful to gain a broader understanding of the pathway and how it is considered useful within the human body.

3. Radtke F, Fasnacht N, Macdonald HR. Notch signaling in the immune system. Immunity. 2010 Jan 29;32(1):14-27. PMID: 20152168


This article talks about the abnormal funtionings of notch signaling as well as current research as to how these are associated with several human disorders including hematopoiesis, lymphocyte development and T cell acute lymphoblastic leukemia. It would be useful to gain more of an insight into current research and how abnormalities in the pathway can lead to dysfunctions within the body.

4. Carlson ME, O'Connor MS, Hsu M, Conboy IM. Notch signaling pathway and tissue engineering. Front Biosci. 2007 Sep 1;12:5143-56. PMID: 17569636


This article talks about the dysfunctions of Notch signaling pathway and how it has been linked to the pathogenesis of several inherited human diseases. It describes the components within signal tranductions plus outlines the role of the pathway and finally summarises current research within the area.

--Z3289642 16:14, 29 March 2012 (EST)

Papers specifically for research