Talk:2012 Group 1 Project

From CellBiology

Group Assessment Criteria 2012

  • The key points relating to the topic that your group was allocated are clearly described.
  • The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  • Content is correctly cited and referenced.
  • The wiki has an element of teaching at a peer level using the student’s own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  • Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  • Relates the topics and content of the Wiki entry to learning aims of cell biology.
  • Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer’s wiki.
  • Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  • The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  • Develops and edits the wiki entries in accordance with this sites wiki guidelines.


Edits

  • Z3333204 153 - Regulation
  • Z3333864 120 - Glossary, Regulation
  • Z3289558 113 - History, Some entries duplicate edits.
  • Z3332676 145 - Glossary, Some entries duplicate edits. Irregular contribution

Total edits - 531

Project page has been accessed 6,000 times.

Positive Negative
  • History and glossary sections.
  • Depth of research on topic.
  • Supporting figures.
  • Structure/layout.


Images

  • Z3333204 - 4 figures including student sketch.
  • Z3289558 - 3 figures, 2 are from inappropriate source.
  • Z3332676 - 3 figures, 1 deleted for copyright issue.

Assessment Items - Some content was correctly cited and referenced. The wiki has an element of teaching at a peer level using the student’s own innovative diagrams, tables or figures and/or using interesting examples or explanations. Both these items have not been fully met.



--Z3332676 14:26, 24 May 2012 (EST) --Z3289558 14:26, 24 May 2012 (EST) --Z3333864 14:27, 24 May 2012 (EST)

--Z3332676 23:47, 23 May 2012 (EST): J. hey, your stereogenesis picture has no description and i dont understand it. Can you put a legend or something on it please. thanks for finding me a picture but you can't use pictures from nature journals. I know theres many pictures but not many of them allow permission to use.

Since we have two pics from wikipedia, we need to remove one of them... I really cant find any pic on 'steroidgenesis', so i think im gonna have to remove your pic jenny. Because there are a lot of pics out there for the Androgen receptor


--Z3332676 21:55, 21 May 2012 (EST) J: hey guys, here is the link of the good testosterone production video that i found http://www.youtube.com/watch?v=djqqao2Uebo. just not sure where to put it. where do you think is the best spot?

Hey can the person who drew the student image add this disclaimer as mark said we needed to. "Beginning six months after publication, I student number: Z3333204 grant the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode." I would add it for you but im not sure how to edit the information once its already been uploaded. Also that videos really good. Maybe you could put it at the end of the signalling pathway section?

Peer Review

Overall I think that the wiki is presented well. Some small issues I can see include:

  1. Small amounts of grammatical errors (which are expected and I’m sure I have some of my own). In the Regulation subheading, a double use of ‘from’ and in Normal Function, ‘development of sexual organs in male fetal‘ could be rephrased.
  2. The timeline finishes in 1994, there must be more recent studies into testosterone or clinical cases that relate, even if less relevant to testosterone signaling, it would be nice to have something up to or near current date.
  3. Again in the Normal Function section, possibly looking into a different way of conveying the information. It is a big slab of writing; maybe some images or diagrams to break it up a little bit will help with the flow when being read. Possibly this is where the hand drawn images can come into play and help explain the message at the same time.
  4. Lines like ‘Testosterone has many function during puberty in males, even though it has similar function in females but the effect is much more significant in males than in females’ could be condensed into something a little easier to read.

Otherwise I think the page is informative, it is not too difficult to understand, key points are covered, layout is as required and research seems to be vast and in depth. I think with some small amendments, the wiki will serve the purpose that is needed.



Introduction

  • Brief, but detailed insight into Testosterone Signalling

History

  • The table layout is great and well referenced, however, the colour might not be too appropriate

Biosynthesis & Regulation

  • I thought these two parts were easy to follow, although biosynthesis was a bit hard to understand. Probably could have included a bit about the Bolded words.

Signalling Pathway

  • I thought this section was nicely structured. It flows, with relevant images and introduces the classical and non classical pathways which ties nicely to the next section.

Normal & Abnormal Function

  • The section for Normal function could have added some sub titles so the readers won't feel too overwhelmed with the extensive texts, but it was informative. The abnormal function provided interesting introduction into the different outcomes.

Clinical uses & Current Research

  • Provides an informative and insightful understanding as to how this relates to the bigger picture. I thought it was a good conclusion to the project.

Intro

  • Good relevant information.
  • Could use more on the actual pathway and to make it flow easier.
  • Image needs a copyright notice.

History

  • Good use of a table.
  • Well referenced.

Biosynthesis

  • Nice step to introduce how we get testosterone.
  • Well referenced again.

Regulation

  • Very simple, may need a little more expansion.
  • Good use of steps to show method.

Signalling Pathway

  • As this is the main area of the study, it could use more info across the board.
  • How do the proteins actually do what they do?
  • Classical and Non-classical pathway could use much more info.
  • Also, try to get images from other places, not so much wikipedia.

Normal Function

  • Good amount of info.
  • Just needs to be read through so that the sentences make sense (a lot of full stops in the wrong place and missing commas and spelling mistakes).
  • Could use an image or two.

Abnormal Function

  • Good topics for discussion.
  • Just needs a little more on each section.
  • Images are always good, could use some.

Clinical Uses

  • Good use of a table.
  • Well referenced.
  • Good succinct information.

Current & Ongoing research

  • Just needs a little bit of tidying up.

Good Glossary and References.



Group 1- testosterone -Many grammatical errors and poor syntax in some sections

-classical pathway table is a good idea but needs an explanation of what you're actually trying to convey. Might be more useful in "signalling pathway" section 

- history is very extensive! Interesting info and presentation makes it easy to read.

-a diagram/flowchart might be more effective for expressing the information about biosynthesis

-layout and formatting is good in Regulation. Maybe consider rephrasing the first sentence

- signalling pathways- "Those outlined below have actions that affect the other"- what is "the other" ?

-the student drawn image is very impressive!

- "Testosterone has many functions during the adulthood life in both sexes. As mentioned previously the effect in males is much more than females" why do you need to repeat this? It doesn't appear to help this section in any way

-a lot of research has obviously gone in to abnormal function and clinical uses

-the layout of Current and ongoing research confused me and as a result did not express your message effectively

-overall well researched and presented




  • Introduction: very interesting, short but distict!
  • History: love the table and detailing but may be to bright??? Good Job!
  • Biosynthesis: I love the table and the image but seems abit hard to understand with all the names that I am not familar with
  • Regulation: very simple, distinct and easy to understand
  • Signalling Pathway: love the structure, love the sub heading, love the diagram and it was very easy to read and understand.
  • Normal Function: May be put them under sub headings or bullet point? It repeats 'Testosterone has many functions...' quite few times and it is confusing to read
  • Abnormla Function: like the detail. It is very easy and simple to read and love the heading.
  • Clinical Uses: Like the overal structure, like how it is put in a table. Easy to read and easily distinguishable.
  • Current & Ongoing Research: I like how it has many ongoing researches but thought it would be better if it had details of where the reseach is happening.

--Z3291200 02:16, 17 May 2012 (EST)


  • Introduction: check grammar – ‘Androgens, with testosterone in particular, have strong affinity for the androgen receptor.’

The introduction is a little clunky and has no smooth flow from one sentence to the next. I’m also left unsure of what you’re going to talk about in your project. Nice picture but if you aren’t going to talk about it and simply dot point out the molecular properties, not describe it, then I think that seems a little awkward for an introduction.

  • History: nice table, nice use of different colours but colour choice seems slightly awkward. Makes the page seem untogether and the history part stands out too much.
  • Biosynthesis: I’m a little unsure of why you bolded certain words. I thought they would be in the glossary but it isn’t. great picture, but should you be referencing from Wikipedia? Maybe find the same thing in a text book, modify it and draw it. Could also be worthwhile mentioning where cholesterol or testosterone comes from in the steroidogenesis pathway so the picture is being useful instead of just looking pretty.
  • Signalling pathway – I don’t think you should get your images from Wikipedia. Other than that, great section, easy to understand and flows well.
  • Normal function – proof read this section – second paragraph, second sentence ‘…. fertility.if testosterone ‘. Also might want to separate this section into having a few subheadings. A massive piece of text with no pictures makes it a little boring and hard to read.
  • Clinical uses – love this section and how you’ve written it and put it into a table. Love the video, made it easy to understand.
  • Glossary – putting it in alphabetical order would make it easier to find the words
  • Images: I like how you did this and put them altogether.
    1. note: I noticed you didn’t have a student drawn image in the project which doesn’t fit the marking criteria. Please remember to do this!

--Z3290558 00:52, 17 May 2012 (EST)

•Introduction is too short but well referenced. This can be further improved by putting more information and giving a brief overview about the topic and what the webpage will be talking about.

•History: Very well formatted and well referenced. Aren't there any other discoveries after 1994 about this topic which you can still include?

•Biosynthesis: Good subheading that other groups do not have. The step by step process made it easier for the audience to understand how testosterone is derived from cholesterol and all information presented were well referenced.

•Regulation: Information were presented in a nice and succinct manner. Maybe adding a picture of the negative feedback mechanism of testosterone regulation will be a good idea.

•Signaling pathway: Like the regulation subheading, this section was presented well. Having sub headings made the division of idea easier to understand.

•Normal Function: This showed a great research about the topic. Putting subheadings will be a good idea as having massive chunks of paragraph looks overwhelming and not very appealing to readers. and The formatting of the paragraph are different. Some paragraphs had 1.5 spacing whilst the others had paragraphs that are single spaced. (this is just minor though).

•Abnormal Function: The abnormal section would look more interesting if there were images for the diseases.

•Clinical Uses: This is a good subheading that other groups did not have. Nice addition to the project. Very easy to read.

•The abnormal section would look more interesting if there were images for the diseases.

•Current and ongoing research: Interesting researches were presented in this section and each were explained thoroughly and the language used makes it easy for readers with very little background about the topic understand the topic well.

•More than one image is taken from wikipedia. (steroidgenesis and The binding of testosterone to an androgen receptor within a cell)

•This project is almost finished. All the section showed intensive research and are explained well.


The overall group work is constructed very well as it is easy to understand the content. The project page demonstrates a good structure as well as satisfying the requirement of the assessment. The use of purple in the history section adds brightness to the page and draws attention to the text. In the biosynthesis section however, I do not see the point of clustering the information into a table as adds messiness to the page. You can simply present the information as dot points. Although the project page obeys the given criteria, one aspect is not followed; Mark clearly indicated that only one wiki image could be referenced in our projects however the images of Testosterone binding to androgen receptor and Steroidogenesis, are both referenced from Wiki. There was no student drawn image on the page.



In order for me to critique the work at hand I am going to take each sub-heading and do so accordingly: -Introduction: The introduction I thought was quite good, how it discussed and explained what testosterone is and how it works. Although I thought it was good, I also thought it was lacking an overview of what the page as a whole would discuss. -History: I liked the table. I thought it stood out on the page and easy to read. The information was short and sweet. EASY to read. -Biosynthesis: I thought this section was difficult to comprehend. It was hard to grasp. -Regulation: I thought this was well done. A diagram would be a great idea to go with the theory. -Signalling pathway: This area needs some work. I think it needs to be broken down into simpler form (as in this and that). Not into too many pathways. -Normal function: This was good. The information was good and I could see was researched. -Abnormal function: I thought this was well structured and easy to read. -Clinical uses: This was good, thought it explained a lot and did so very well. -Current and ongoing research: This section was researched well. It showed me that they understood what testosterone does and how it can be used for research. -I think this project was really good and shows the rest of us that we have to really pick up our game.



Introduction – articulate intro but there needs to be copyright details for the image

History – the table was a very great idea it broke everything down and the colour made it a little more fun + well researched

Biosynthesis – liked the correlation between the table and picture, correctly referenced however maybe put this subheading under something else, im not sure it needs its own section?

Regulation – coherent and easy to understand as well as correctly referenced, not as much information but I don’t think it needs it

Signalling Pathway – liked the use of subheadings

Normal Function – I think you need a picture or a table to break the writing up make it a little more visual

Abnormal function – liked the use of subheadings

Clinical uses – the table was a very good idea, information was succinct and well referenced, the video link was a good idea made it more exciting for the reader

Current and ongoing research – informative and easy to understand

Glossary – a very good idea

Images – that one image (same image as before) must have copyright details

References – an impressive list

Overall - an extremely succinct and well-researched project, be a little careful about grammar and in-text citations


  • Introduction: Very well explained, covers all relevant content and a good summary of testosterone. Maybe try add an interesting point about testosterone to draw the reader in.
  • History: The history is well researched and instead of just providing a list of discoveries, you outlined the importance of each one. It is clear that a lot of effort went into this section. There is a large gap between 1767 and 1849, as well as from 1994 until the present. What happened during these periods?
  • Biosynthesis: This section is very difficult to follow. A diagram illustrating each point would allow the reader to picture the structures and better understand the process. The image needs an explanation. Other than that the information is well presented as a table, and the key points are in bold which helps identify the the important information.
  • Regulation: The ideas are easy to follow and the information is easily understandable (as opposed to the Biosynthesis section). The only thing to improve here would be to add either spaces or headings between the paragraphs to break up the text.
  • Signalling Pathway: Although there is a lot of text in this section, the layout breaks it up nicely and provides structure to the information. The images are highly relevant and contributes to the readers understanding. This section was very well done!
  • Normal Function: This section is very overwhelming in terms of reading information and lacks structure. I suggest you have a look at the layout of the 'signalling pathway' section and add features such as headings, bullet points and images to make it more appealing to read.
  • Abnormal function: Each point is well researched and clearly explained. I think the addition of statistics involving the prevalence of each disease and the impacts they have could make the information more relevant and interesting for the reader.
  • Clinical uses: A very nice summary of clinical uses of testosterone. The video is very relevant and is a nice feature of this section.
  • Current and ongoing research: This section lacks an introduction and general layout structures such as headings. Links to the research papers would be useful, as well as more citations to show the depth of research involved.
  • Overall impression: Whilst some areas are very well done, there are a few sections which are letting you down. Mostly it is just to do with the layout of the information to make the page more appealing to read and easier to absorb the flow of information.




  • Introduction: Well summarised and good use of sources. Need to add copyright info for the image.
  • History: very informative and research is quite extensive. I like the table format, not too sure about the colour. But it does make the website more inviting and interesting.
  • Biosynthesis: this section is overwhelming with scientific jargon. Perhaps adding some of the words such as hydrogenation to the glossary could really help people to understand. Include copyright information for the image.
  • Signaling pathway: i like the layout of this section and the use of appropriate images (both of which are correctly cited. I also noticed there are two wiki images?)
  • Normal function: appears very dense and full of information. Maybe consider playing with the layout by adding images/tables
  • Clinical Uses: table is very useful in summarising and organising the information. The video is a great touch!
  • Current and ongoing research: I think this section needs a little introduction before diving into the research content. It could really benefit from some sub-headings or in-text citations just to reinforce the studies already summarised.
  • Glossary: bit short, but coming along well. Don't forget to arrange them in alphabetical order.
  • References: double check some of your references. E.g. No. 2 is a dead link and also 20, 22, 26-27 need proper references.

Overall the page was very interesting and generally well presented. Just a few changes needed.


what was done well:

  • the history section was very well organised and gave an insightful, yet brief summary of the discoveries over the last century
  • The biosynthesis was educational. It wasn't too detailed and easy to understand because of the table
  • The dot point structure of the signalling pathway made a complex section of this project easy to understand.
  • the PNAS image was correctly cited and relevant to text

what needs to be improved:

  • the introduction is too brief. Besides just adding in a table and some points about the properties, can you please add some linking sentences to tie the structure and pathway overview together? For example, 'there are two pathways for testosterone signalling as shown in the table below'
  • I feel you need more pictures and diagrams. For example flowcharts for the 2 pathways. Keep in mind you do need 1 student drawn diagram - maybe do that for the testosterone structure instead of using a non-copyrighted image
  • can you find some images besides wikipedia images?
  • Add some subheadings for Normal Function or a table summarising the functions at the start. Testosterone has many functions so it would be more easier to find information if it was better organised.
  • Add more in text citations - you can't put 1 reference at the end of each paragraph (seen in 'Normal function') because each sentence that includes idea from a paper needs an in-text citation.



I can tell from the wording that the history was not just regurgitated, but that the writer took the time to synthesise and summarise the content in the tables. Also regarding "normal function", the section is clear and well set out and easy to read. I found the use of tables in "clinical uses" to be effective in presenting the current clinical uses of testosterone.

However, there are also some areas that need improvement or modification. Aside from the spelling, punctuation and grammar errors (which should be fixed, by the way), where's the citation for figure 1? Also, the second citation in the reference list didn’t properly show up. And I also noticed you have two wikipedia images - we're allowed a maximum of one, so take at least of them off if you don't want to lose marks. You might also like to add a citation to the testosterone structure image. There are numerous other places with incorrect referencing as a result of incorrect coding, or sometimes no attempt at finding the reference at all.

I'm not sure you need a table under "biosynthesis".. Sometimes less is more. Also and instead, I would prefer to see subheadings for the four steps you mentioned. That would be helpful.

What would also be helpful would be a diagram for the "regulation" section from the peer reviewed literature supporting what you're writing.

Also, take "proteins" and "structure" out of "signalling pathway". They're not elements of the pathway! Put them under a different section, or make separate sections for them.

Finally, I think a few external links wouldn't do you harm, to such web pages as maybe major facilities/journals/institutes for the research of testosterone, or complementary info or diagram web pages.

Hope that helps.



  • Pros
    • Well formatted tables
    • Comprehensive “Current and Ongoing Research” section
    • Content correctly cited and referenced
  • Cons
    • No copyright information included for testosterone structure image under “Introduction”
    • Two Wikipedia images used
    • No student-drawn image
    • Needs proof-reading (e.g. “1994 – History” “...also identified testosterone and a risk factor for hypotension and obesity”
    • Image titled “Steroidogenesis” very complex, maybe draw own simple flow diagrams for each of the steps of the biosynthesis pathways?
    • Also could draw simple flow diagrams to describe signalling pathways (e.g. “Classical” and “Non-classical”) to make the information easier to read and understand



  • Intro seems disorganised, you are trying to give away too much. formatting needs to suit the section and i don't think a table should go into intro. properties should be in another section. i like the inclusion of the image of the molecule.
  • History table is great, its colourful and content is really well researched.
  • Biosynthesis, a very detailed table, maybe instead of such a complex image you can make a student drawn flow chart of the steps and place that next to the table or within the table as another column.
  • Regulation is very simplified, may you should elaborate some more here, add an image or graph of the differences with testosterone high vs low.
  • Signalling pathway has been done very well. its clear with subheadings, bullet points, and images are eye catching.
  • Normal function appears like a big slab of text which i have no intention of reading, you need to make people what to read it, add bullet points, images like the other sections of this project.
  • Abnormal function also well done but requires some images or something to break up all the text, but good use of subheadings.
  • Clinical uses table is very comprehensive, and seems easy to read and understand.
  • I do have issues with this section, i really don't understand what you are saying, what research you are talking about when you say "In a recent study, both injection and oral testosterone were compared to demonstrate their differing effects." etc. i don't understand the numbering (what are these sentences relating to?) when you say this study was done... you should post the reference for the study either with the paragraph or as a citation. Its very confusing, i don't know how many articles you are referring to.

In the introduction the sentences can be rearranged to sound more logic and to make it easier to read.

Please provide copyright details on your picture “Testosterone structure”.

Your history is expansive and well-organised in a colourful table. This encouraged me to read it! Well done!

I found your biosynthesis section a little difficult to read. Some of the terms mentioned there should be explained in the glossary of terms. Another option would be to edit that section and make it more understandable for those who have not put the research into this topic and hence have less knowledge regarding testosterone signaling and the various elements involved.

Your picture on “Steroidogenesis” does seem relevant but please make sure you provide the copyright statement.

Regulation is well-explained and the steps are easy to follow. Just as a suggestion: maybe provide a picture showing where these organs are located in the body. But besides that well done.

The signaling pathway contains the “structure of the receptor”. You might be better of putting this near the introduction and including a schematic picture of the receptor.

The picture “binding of testosterone to an AR within a cell” is very helpful in this section. One thing to notice is that you’re only allowed to use one image from wikipedia. "Steroidogenesis" was also a wikipedia image. I would encourage you to change the binding of testosterone image – maybe make it a student-drawn image as you don’t have one yet.

The image “testosterone induced phosphorylation” has the correct information provided – including copyright - so that's great.

From normal function onwards you have a lot of information, which is excellent! However, without pictures this does make it a little less encouraging to read. Put in some images relevant to the text, for example provide a picture on prostate cancer where you explain the abnormal function.

Clinical uses looks organized and is well-written to make it understandable for the audience. The video link provided is also an excellent attribute!

Current and ongoing research contains a lot of text with insight into recent studies which were undertaken. All the information is good, however, if you could include an image this would make it more attractive for the audience to read it.

You used a good range of sources but do make sure your references are correct. In particular have a look at 20, 22, 26 and 27 as I can only see a website in the reference list.

Overall, well done. There is a lot of information regarding testosterone signaling. Please do check your spelling and grammar and take into account the copyright statement for the images. Notice that we are allowed to use only 1 wikipedia image and we are required to provide at least 1 student image. More images makes it look more attractive and would persuade the audience to read it.

Kind regards


The whole page seems very organised, and is very easy to follow throghout.

The first thing I noticed was the explicit use of tables which made the information easy to comprehend.

The subheadings in particular for signalling pathway along with the bullet points make the paragraph organised.

It would be great to see the same thing under the heading "normal function" as it is difficult to read the extensively long paragraph without any subheadings.

The Science behind "clinical uses" seems to be accurate, and quite understandable.

All the words which I thought should be in the glossary were explained in a way that could be understoond by everyone.

The referencing and copyright all seem to be accurate, and very well done. An excellent page.

However, what I would like to see is which institutes are carrying out the research.

Although it is thouroughly explained, it fails to name who is taking part in the study and who is conducting the study.

A few internal and external links would be good to add in this assignment.

Good luck with the rest of the assignment.


Feedback on the page:

The introduction is very brief but I like how you have given the chemical properties of testosterone. The first and second image need copyright information. Also I think we are only allowed one image from wikipedia whereas your 2nd and 3rd are both from wiki so you might want to consider changing one of them. The table makes the information very easy to read but the colour is a little too bright.

Your signalling pathway itself doesnt have a lot of information so try elaborating a little bit. On the other hand there is too much info in the normal function so just add some headings to divide the section. The abnormal function and clinical uses are beautifully laid out. Just organise the research section a bit better because it seems like there are 2 sections but its a little vague.

Overall its looking good but organising a few sections will make it much better.



  • Introduction is clear and concise, giving the information I would expect from and intro – not too in-depth but giving a good overview however (take this with a grain of salt as I am uneducated in the topic) but perhaps more should be introduced about testosterone signaling as opposed to just the hormone testosterone. While the image provided has a link, it is missing copyright info.
  • The history section does draw you in, and the information contained therein is good, however while good on its own it does not really fit in with the rest of the page and I do not see any information/meaning of the history section being taken away if the colour was removed.
  • Information contained in the biosynthesis section is good from what I can see however the terms used here being put in the glossary would be good. The table format is quite unnecessary; you can simply list out the steps 1/2/3/4, no need for the table which squishes the info together.
  • I feel as if perhaps more information should be added to regulation, perhaps an elaboration on how it is regulated/more on why it needs to be regulated or what causes testosterone levels to be high or low.
  • Pathway section appears to have a good amount of information in a nice format with appropriate subheadings; images are useful however there is a second wiki image being used.

There are a few grammar issues in the normal function section, aside from this the information contained is good. If possible a few subheadings to easier group the information could be useful.

  • Abnormal function section is done well from the uneducated observer perspective.
  • Clinical uses, like abnormal function is done well, however perhaps putting them in the same format would be ideal given they are presented similarly, that is, perhaps put abnormal function info in a table like that of clinical uses, or simply take the clinical use table and have it as subheadings followed by relevant information – the table, although there is nothing wrong with it, is not necessary. The video is a good example of a useful external link.
  • The numbered points at the start of the research section are mildly confusing in their odd placing, perhaps cutting those points into an introduction as to why research is being done could be more useful. Aside from this, a few formatting edits could improve the section.
  • The glossary is decent and simply needs to be finished off.
  • Reference section has a few errors, 2nd reference is missing/broken. While I understand that the references for 20/22/26 are to a database, perhaps name the database, linking to the inserted link would be better, if not “date accessed” can be put in. For Ref 27, a reference for the paper as opposed to a link to the paper would be better.



  • Introduction: Ideally the introduction should provide an overview of the whole signalling pathway with an explanation of what this page aims to do. This provides direction for the audience. Although I quite like the idea of introducing testosterone as a molecule, it would be more effective if you had a separate section explaining the properties of testosterone perhaps in a table format.
  • History: The colour scheme of the table is very eye catching and the information is concise and well summarised. The history section could be improved by adding a couple of more entries after 1994 and expanding the history.
  • Biosynthesis: The idea of having this section is great however the content is not very user friendly especially for people who are new to biochemistry and testosterone signalling. I suggest simplifying the steps and adding a student drawn image depicting the pathway. You could even have each step correlate to numbers on the student drawn diagram.
  • Regulation: Again – another fantastic idea! What could really make this section shine is the addition of a diagram of the hypothalamic-pituitary-testicular axis. I think a good physiology textbook is a great source of inspiration.
  • Signalling pathway: This section needs revision. I suggest focussing on the two pathways: classical and non-classical which could be presented as a diagram or in steps (like in the biosynthesis section). Introduce new sections for the proteins and receptor structure.
  • Normal function: Well written and researched information – all this sections needs is more structure and organisation to make it more user-friendly.
  • Abnormal function: I like the way this section has been organised into subheadings. Good job.
  • Clinical uses: This section is very informative and well structured. The highlight of this page!
  • Current and ongoing research: As a whole, this section demonstrates good research however the expression of ideas in a concise manner is lacking. At times, the sentences are a little confusing however this can be easily remediated with some editing. Another great component to incorporate in this section is the graphs and diagrams from the studies to back up the research.

Overall, a marvellous effort! Your referencing is consistent with a great range of resources being used however please revise your list before the final submission to take care of some broken links or incomplete references.


Order of headings makes it easy to follow, and the text is well referenced throughout. Not sure what ‘steriodogenesis’ diagram is for, it appears rather complicated. A few punctuation and grammatical errors were observed in the normal function section but that can easily be fixed before the due date. Also, there was no student drawn image on this page, which is required. The use of subheadings breaks up the large sections of text – effective way of keeping the reader interested. Displaying the history and clinical uses in tables is also an effective way of breaking up large sections of text.



The first sentences you have, they start all almost the same. Moreover I can’t really find copyright for the picture. You should work on the references in the introduction part, too. I liked the colorful table in the History part but I think it would be better to lighten the dark purple, so that it’s easier to read the letters. To illustrate the History part it might also be nice, to insert some pictures. To the Biosynthesis part I might refer to my critic from the introduction: also here most of the sentences have the same beginning “this”. You should correct that, because then it is more exciting to read as when it starts always same. The part “Non-clinical pathway” contains information about studies, which could either occur into another part “further research” or brought more into context; you mention different studies or points of research throughout also in other parts- I would prefer reading about all them in one part then every time a little. Furthermore, you should improve the part “normal function”: here are sentences that are not yet finished. In the second paragraph, you should correct the capital letters after punctuation and leave a space in between them! However, I like how you built up this part from a baby to a grown-up. Throughout your page you mention, that Testosterone affects women and men but then you only relate to men. In my eyes, you should either at least mention how it concerns women or leave it out. By mentioning it multiple times the reader becomes curious, by not giving explanations then the reader becomes disappointed. Another point is that you refer to articles and studies in your research part but you do not name them. I think you should mention it once and correspond to it afterwards, to make it easier to follow. All in all I think your group should over read the whole page themselves. There are a couple of little things that can be made better by rereading it. There are a lot of repetitions in words or structuring which are pretty obvious when you put in a little effort.


The introduction is well-explained but much too short - you may need to expand on it. The history seems well-researched. Great idea to include a colorful table as it is visually pleasing. I like how you broke down the biosynthesis section, as well as included an image to make it easier to understand. In addition, the sections on regulation and signaling pathways are detailed and easy to read. The general formatting of normal functioning, abnormal functioning, and clinical uses is fine, but you might want to include more pictures in this section, as it is a little bit difficult to read such a large chunk of text. The section on current and ongoing research needs some improvement. It would be helpful to have a short paragraph before you go into the numbered list. For the glossary, just ensure that you keep the formatting the same for all terms. That is, some words have colons and others do not - choose one. Overall it seems to be a good project, however, you still need to include a student drawing, use less Wikipedia images, include copyright information on your images, and correct some grammatical and spelling errors.


The main aspects of the marking criteria has been met on a relatively good level. The project page seems to demonstrated interesting propositions with testosterone and a good understanding of the topic seems to be shown. The colouring in the history page allows for easy understanding as well as the images seem to show interesting graphs. There is however, no hand drawn image and grammatical errors in the introduction should be addressed.


Hey i was thinking i could use some of the stuff in the current research section in the clinical uses section but i dont want to move others peoples work, is it ok if i use what you have written about testosterone treating depression in the clinical uses section?

Hey guys this is a good video explaining the effects of low testosterone and some of its clinical uses. http://www.youtube.com/watch?v=2Gva_lAUrAg&feature=results_main&playnext=1&list=PL770BA47AEB86ACF9 I was thinking of posting it as an external link at the bottom of the clinical uses section. Also how is everyone going with their parts? are you going to have them up for peer review? If you need any help let me know.

--Z3332676 17:41, 9 May 2012 (EST) hey guys, this is a good review http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871922/

--Z3332676 23:18, 2 May 2012 (EST) ok. There is also androgen insensitivity syndrome-a mutation in the androgen receptor that causes it to not respond to androgens-testosterone.

I know theres an article posted in the abnormal func. section, if the person who posted it wants to put their summary into dot points? or dot point the relevant info from that article in their own words.:) sorry that im slow with my section(signalling pathway) I'm trying to look at more articles for information on what to write.

i think dot points for certain parts will make the information layout clear, and easy to read. Do you guys agree?

also i've noticed in the intro theres a note about the anabolic pathway. I'll have a look into that because i havent come across that in my articles unless they've been referred to as the non-classical pathway?

Hey, yeah Dot points sounds good. Ill finish off the clinical uses section tonight with what M has already done. Then maybe i can add some more dot points to the current research. Do you want any help with the signalling pathway?

The binding of testosterone to an androgen receptor within a cell

--Z3289558 22:48, 30 April 2012 (EST)p. Hey guys: we can use this info as a starting point for adnormal testosterone levels or functioning: "The most frequent causes of testosterone deficiency include tumors and other disorders of the testicles, pituitary gland or hypothalamus and Klinefelter's Syndrome. Symptoms of testosterone deficiency include decreased energy, depressed mood and decreased libido."-http://www.medrehab.com/Description_Testosterone.php

Just added a pic I thought was relevant. --Z3332676 23:36, 18 April 2012 (EST)-J

So from the info i've found I've started the structure and parts of the signalling pathway because the articles sort of combine the two together.

ok well i've started looking for info on the structure of the receptor but i'll try to find more general info for our intro etc. there's already P looking into history. Maybe someone can start finding info/articles on the pathway and we can edit it together. --Z3332676 12:15, 8 April 2012 (EST)


ok guys, lets start dumping in everything we've been discussing for the past 2 weeks on this discussion page.

start choosing your areas of preference (so if your interested in doing the HISTORY) just say so.... and also we need to upload an image ASAP

Lets start with some general information about testosterone signalling, then we'll choose a specific pathway

--Z3289558 10:43, 12 April 2012 (EST) Hey, didn’t mark say we could look at both testosterones signalling in spermatogenesis as well as its role in differentiation of the external genitalia? Are we going to focus on just one area?

Also I would be interested in looking into testosterones history and the pathogenic effects of testosterone.


--Z3289558 20:14, 19 April 2012 (EST) Hey, I was thinking, we should not only look at the pathological effects of abnormal testosterone levels, but also look at how testosterone can be used in prevention or treatment of certain disease. Here are two articles i found relating to testosterone use in alzheimer patients:

1. <pubmed>15985573</pubmed> 2. <pubmed>10655508</pubmed>

--Z3332676 00:53, 24 April 2012 (EST) J hey, I don't think we don't need to focus on just one area but i can't really remember what mark said the others probably do. But it might be easier to focus on a few certain areas or one broad one. Just so its not too much put together. Also testosterone as a prevention for certain diseases sounds good. That can be another heading or put with current/future research if there's still research in the area, I'm guessing there is.

--Z3289558 13:19, 25 April 2012 (EST)Yeah we should probably just put that under current research, or we could make a new subheading called clinical uses? it just depends how much info we find.

Hey guys, this is what ive done for the history so far, Im not sure how much of the current research i need to add to the history section seeing we have a seperate section for that. Anyway im still working on it but let me know if its ok.

History

1767- John Hunter performed the first intention testicular transplantation, however physiological effects were not studied as he was more interested in the techniques of tissue transplantation.

1849- Arnold Berthold postulated that the physiological and behavioural changes of castration were due to a substance secreted by the testes, and further determined that this substance must interact with the body through transmission in the blood stream

1889- Charles Edouard Brown-Séquard prepared a solution of testicular extracts that he subcutaneously injected. After 3 weeks he reported an increase in strength and a decrease in memory loss, insomnia and other signs of aging. This extract become known as “the elixir of life”, and although other scientists were sceptical of its effects, this research promoted much more experimentation within the field of orgnotherapy.

1902- William Bayliss and Ernest Starling recovered an extract from duodenal mucosa which they named secretin. They observed secretins physiological effect and postulated that the extract was a blood borne chemical messenger which acted on a target tissue to elicit the observed effect. William B. Hardy later proposed the term hormone for these chemical messages and in 1905 the name was first published in an article submitted by Starling in the lancet.

1929- Adolf Butenandt isolated estrone-the first pure sex hormone, followed by androstenone. In 1934 Leopold Ruzicka synthesized androstenone. The work by Butenandt and Ruzicka not only proved that hormones could be isolated, but that they could be synthesized and therefore easily implemented in modern medicine.

1935- Kàroly Gyula David, E. Dingemanse, J. Freud and Ernst Laqueur first isolated and named Tesosterone and published a paper titled: “On Crystalline Male Hormone from Testicles (Testosterone),”. Later in that year, Adolf Butenandt synthesized testosterone and published “A Method for Preparing Testosterone from Cholesterol”. A week after Butenandts paper was published Ruzicka and A. Wettstein published their own article describing the synthesis of testosterone and therefore, in 1939 both Ruzicka and Butenandt were offered the Nobel prize for chemistry. Butenandt however, was forced to decline the award due to the Nazi government.

1951- Charles D Kochakian published “Recent Studies on the Vivo and in Vitro Effect of Hormones on Enzymes” indentifying androgens as stimulators of the protein anabolic processes. Following the publication of this article, many scientists have looked into the use of androgen therapy to restore protein and stimulate growth in patients suffering from a number of diseases.

1950’s- Anabolic steroids such as testosterone become widely used by athletes to increase muscle mass.

1960- Invention of the Radioimmunoassay allowed researches to efficiently measure the endogenous levels of testosterone. Shortly after this, methods were developed to measure testosterone through saliva samples. Saliva radioimmunoassays made research on humans simpler and less invasive by avoiding blood assays for testosterone.

1994- Department of Medicine at Columbia University reported that low levels of free testosterone correlate directly with in increased incidence of coronary artery disease. They also identified low testosterone and a risk factor for hypotension and obesity.

1997- Development of the Transdermal method for Testosterone replacement therapy.


--Z3332676 09:47, 26 April 2012 (EST) (DRAFT) this still needs editing but this is what im working on.

Testosterone is an androgen hormone that plays an important role but is not limited to, male reproductive development and spermatogenesis. Testosterone has been shown to act in two main pathways often referred to as the classical and non-classical pathway. Through the classical pathway, testosterone acts via the androgen receptor (AR). These AR can be found in high numbers on sertoli cells in testis and leydig cells in seminiferous tubules.

The Classical Pathway

Through this pathway, androgen hormones such as testosterone or dihydrotestosterone (DHT) bind with an AR resulting in a conformational change in the AR structure. DHT is a converted form that is carried out by 5a-reductase, an enzyme found in the cytoplasm. Upon binding, an activated complex results that has a greater binding affinity to hormone protein elements found in the nucleus that are necessary for the androgen receptor’s role in gene transcription.

<pubmed>15263086</pubmed> --Z3289558 17:43, 28 April 2012 (EST) Hey so i was just wondering what sections everyone is working on? I know J is doing work on the pathway and I am doing history and current research. I just don't want to double up on any work.


--Mark Hill 11:23, 4 April 2012 (EST) Dear Group 1, As of Wed 4th April (week 5) other than the requested individual assessment references there is nothing on either your project page or discussion page that indicates that any work has been carried out on this project since its inception. I remind you of the assessment criteria and my expectation of ongoing demonstrable contributions.


  • The key points relating to the topic that your group was allocated are clearly described.
  • The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  • Content is correctly cited and referenced.
  • The wiki has an element of teaching at a peer level using the student’s own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  • Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  • Relates the topics and content of the Wiki entry to learning aims of cell biology.
  • Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer’s wiki.
  • Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  • The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  • Develops and edits the wiki entries in accordance with this sites wiki guidelines.

Group 1

Since most peer assessments before me have given orderly and insightful feedback for each subheading and section of the project, I wish to do my feedback differently. Unlike most before me, I am not going to go through each section and comment(which has been helpful), but rather I am going to see how the whole project scales up against the marking criteria provided by Mark at the start of semester. This different style to all the other peer assessments will hopefully allow the groups to align their projects with the criteria and will provide a new viewpoint and perspective for them to work from. Thanks.

• Firstly, good choice of topic, especially with the London Olympics coming up and all the cheating that goes on now days. Maybe, just for the readers interest and curiosity, include a brief segment on advantages and disadvantages of getting on the ‘roids’ and how cheats use it these days

• Key points and their descriptions are all present and explained clearly. Since the focus is cell signalling, it would enhance the projects quality if you included a little extra on the intracellular signalling and pathway which results from testosterone binding to its receptor.

• Citation and referencing is done extensively, appropriately and correctly, with a good range of articles from recent years 1990s-2011(therefore up to date information is guaranteed)

• Good images/text ratio and an appropriate level of depth and detail is employed, except in the signalling pathway

• Follows Wiki guidelines in format, editing, structuring, referencing and has that ‘element of teaching’ that Mark has asked for

• Overall, well rounded Wiki page which to adheres to the learning aims of Cell Biology , but it will need to be run through a fine tooth comb (grammar, structure) before submission, just to polish it up to the same level of effort that seems to have gone into its making.

Group1: - effect use of tables throughout - clear and concise information in the regulation, pathway and abnomal function sections - normal function section is a bit wordy and still has some spelling and grammatical errors, subheadings might be useful to organise the info here - current research section is a bit confusing and hard to read, i would suggest using subsections for each study you mention to help with the format and perhaps some external links - still require sstudent drawn image - referencing is inconsistent and lacking in some areas

reviews

--Z3332676 21:43, 4 April 2012 (EST) hey guys,

Here's a review that seems pretty helpful.

<pubmed>19095000</pubmed>

Homework sources

--Z3289558 10:20, 26 March 2012 (EST) -P

1. <pubmed>11176375</pubmed> This article is a good source for an integrated history of testosterone.


2. <pubmed>12017541</pubmed> This article investigates the hormonal regulation of spermatogenesis and identifys testosterone as an essential component.


3. <pubmed>1425487</pubmed> This source provides a detailed explanation of the gene expression mechanisms of steriod hormones such as testosterone. This information can integrated with our knowledge of testosterone's hormonal regulation in spermatogenesis.


4.<pubmed>22421515</pubmed> This article provides a broad overview of the effects of testosterone deficiency and the pathological effects it has on the body.

CTRP3 is a molecule found in high concentration in adipose and causes increase in production of testosterone.

1. <pubmed>22342437</pubmed> This article explains how testosterone increase the muscle mass and circulation of GH and I-GFI in the blood.

2. <pubmed>21084444</pubmed>

Phthalic acid esters are used in production of plastic. studies shows that phthalates impair testicular testosterone production in the rat. This article looks at the effect of Phthalic in man.

3.<pubmed>22402212</pubmed>

This article looks at the effect of testosterone in older men and testosterone replacement therapy and its benefits.

4.<pubmed>22430839</pubmed>


z3333204

1

<pubmed>21554430</pubmed> Description: The article talks about the effects of the use of anabolic androgenic steroids, mainly concerned with the regions in the brain that are being activated. This is related to our topic of testosterone signalling involving the neural pathways involved

2

<pubmed>21651570</pubmed> Description: The article talks about the importance of androgen signalling in the differentiation and function of adult Leydig cells. The synthesis of testosterone is dependent on the development of these Leydig cells, hence understanding the mechanisms involved is essential in grasping the idea of testosterone signalling

3

<pubmed>22319659</pubmed> Description: This article talks about testosterone signalling and its involvement in spermatogenesis. The article is mainly concerned with the main cellular target of testosterone signalling, being the Sertoli cells

4

<pubmed>22405892</pubmed> Description: The article talks about several molecules that are involved in the testosterone signalling pathway, such as seladin-1, in which its expression is severely moduled by the effect of testosterone


z3332676- J

1 Marina Grigorova, Margus Punab, Birutė Zilaitienė, Juris Erenpreiss, Kristo Ausmees, Valentinas Matuleviĉius, Igor Tsarev, Niels Jørgensen, Maris Laan Genetically determined dosage of follicle-stimulating hormone (FSH) affects male reproductive parameters. J. Clin. Endocrinol. Metab.: 2011, 96(9);E1534-41 PMID:21733993


The effects of the low level of follicle stimulating hormone (FSH) on the male reproductive system. It shows the indirect role of testosterone and FSH.


2 M Scobey, S Bertera, J Somers, S Watkins, A Zeleznik, W Walker Delivery of a cyclic adenosine 3',5'-monophosphate response element-binding protein (creb) mutant to seminiferous tubules results in impaired spermatogenesis. Endocrinology: 2001, 142(2);948-54 PMID:11159868


Examination of the role of cAMP response element-binding protein (CREB)in spermatogenesis.


3 W P Benten, M Lieberherr, G Giese, C Wrehlke, O Stamm, C E Sekeris, H Mossmann, F Wunderlich Functional testosterone receptors in plasma membranes of T cells. FASEB J.: 1999, 13(1);123-33 PMID:9872937


The presence of testosterone receptors on T-cell membranes suggesting the potential of testosterone being involved in immunity.


4 Robert W Holdcraft, Robert E Braun Hormonal regulation of spermatogenesis. Int. J. Androl.: 2004, 27(6);335-42 PMID:15595952

Review

The role of testosterone in spermatogenesis.

CTRP3 is a molecule found in high concentration in adipose and causes increase in production of testosterone.

1. <pubmed>22342437</pubmed> This article explains how testosterone increase the muscle mass and circulation of GH and I-GFI in the blood.

2. <pubmed>21084444</pubmed>

Phthalic acid esters are used in production of plastic. studies shows that phthalates impair testicular testosterone production in the rat. This article looks at the effect of Phthalic in man.

3.<pubmed>22402212</pubmed>

This article looks at the effect of testosterone in older men and testosterone replacement therapy and its benefits.

4.<pubmed>22430839</pubmed>



Endocrinology http://www.ncbi.nlm.nih.gov/books/NBK22/


peer assessment Group 1

Since most peer assessments before me have given orderly and insightful feedback for each subheading and section of the project, I wish to do my feedback differently. Unlike most before me, I am not going to go through each section and comment(which has been helpful), but rather I am going to see how the whole project scales up against the marking criteria provided by Mark at the start of semester. This different style to all the other peer assessments will hopefully allow the groups to align their projects with the criteria and will provide a new viewpoint and perspective for them to work from. Thanks.

• Firstly, good choice of topic, especially with the London Olympics coming up and all the cheating that goes on now days. Maybe, just for the readers interest and curiosity, include a brief segment on advantages and disadvantages of getting on the ‘roids’ and how cheats use it these days

• Key points and their descriptions are all present and explained clearly. Since the focus is cell signalling, it would enhance the projects quality if you included a little extra on the intracellular signalling and pathway which results from testosterone binding to its receptor.

• Citation and referencing is done extensively, appropriately and correctly, with a good range of articles from recent years 1990s-2011(therefore up to date information is guaranteed)

• Good images/text ratio and an appropriate level of depth and detail is employed, except in the signalling pathway

• Follows Wiki guidelines in format, editing, structuring, referencing and has that ‘element of teaching’ that Mark has asked for

• Overall, well rounded Wiki page which to adheres to the learning aims of Cell Biology , but it will need to be run through a fine tooth comb (grammar, structure) before submission, just to polish it up to the same level of effort that seems to have gone into its making.

Group1: - effect use of tables throughout

- clear and concise information in the regulation, pathway and abnomal function sections

- normal function section is a bit wordy and still has some spelling and grammatical errors, subheadings might be useful to organise the info here

- current research section is a bit confusing and hard to read, i would suggest using subsections for each study you mention to help with the format and perhaps some external links

- still require sstudent drawn image

- referencing is inconsistent and lacking in some areas