Talk:2011 Group 1 Project

From CellBiology

Post Peer Assessment Discussion

Hey guys in response to the peers i moved around my pictures, gave them text under them, and added a lot of new information and some photos to the structure section. the only issue we have left is to clean up our reference list since it mostly looks like a bunch of pubmed IDs. i guess we will ask mark what to do with this.--Michael Orenstein 21:48, 25 May 2011 (EST)

Week 7

  • This is the week before the mid-session break.
  • In the lab this week we will have an opportunity to discuss any issues which are slowing progress on your project.
  • The Thursday of the week beginning 02 May will be when all projects will be open to Peer Assessment.
  • What you have on your page by Thursday of that week will be the content that others in the class will comment upon.

Week 6

  1. I see many groups now have subsection titles for their projects.
  2. Here are some searches: Pubmed search all databases junction | PLoS junction | JCB junction You can now simply put your own search term into each top window.
  3. Now's the time to get your images, movies, media etc uploaded. Biomed central | JCB | JCB Archive | PLoS. Once uploaded you can make a gallery on either your project or discussion page using <gallery>File:name here</gallery> tags with your image files listed between the tags. When you upload project images, add this text as it appears replacing # with your own Group number to the summary information [[Category:2011Project#]].
  4. Shown below are the criteria that will be used to assess your final project.

Group Assessment Criteria

  • The key points relating to the topic that your group was allocated are clearly described.
  • The choice of content, headings and sub-headings, diagrams, tables, graphs show a good understanding of the topic area.
  • Content is correctly cited and referenced.
  • The wiki has an element of teaching at a peer level using the student’s own innovative diagrams, tables or figures and/or using interesting examples or explanations.
  • Evidence of significant research relating to basic and applied sciences that goes beyond the formal teaching activities.
  • Relates the topics and content of the Wiki entry to learning aims of cell biology.
  • Clearly reflects on editing/feedback from group peers and articulates how the Wiki could be improved (or not) based on peer comments/feedback. Demonstrates an ability to review own work when criticised in an open edited wiki format. Reflects on what was learned from the process of editing a peer’s wiki.
  • Evaluates own performance and that of group peers to give a rounded summary of this wiki process in terms of group effort and achievement.
  • The content of the wiki should demonstrate to the reader that your group has researched adequately on this topic and covered the key areas necessary to inform your peers in their learning.
  • Develops and edits the wiki entries in accordance with this sites wiki guidelines.


By Week 5

Each Group member has added to the discussion page:

  1. A Review Article
  2. A Historic Research Article
  3. A Current Research Article

No two students should add the same paper and there should be a link to the original article.


Hey i know .. I already fixed up some of the things I was told to and I am about to add the ref for my part .. as for why some said my pics have no copyright info .. i still do not understand .. !!

Hey guys!

We got some great feedback! Here are some things I will work on following this;

Reference history, make it longer (just add more recent things) and include link

Better define synaptic integration and modulation. Make Intro clearer

Grammer Intro of whole project should be a bit clearer

Add to glossary

Can put links in legend of picture

What do u guys think? also, I've kinda got a busy w/e with work and other assignments, so I'll work on it mon, tues, weds of nxt week =)

--Mark Woods 20:59, 20 May 2011 (EST)


Peer review

Group 1:

  • Introduction is good since you give a good outline about the nervous system and what a synaptic junction is, could say a bit about what the page is going to outline aswell. Big picture like that at the beginning draws the reader in, maybe in the intro write what its actually showing.
  • Good use of pictures throughout the project page to break up the text and keep the reader interested.
  • History is detailed but is there anything occurring from 1981-present?
  • Introduction, history, neurotransmitters headings need referencing!
  • Description of what a synaptic junction is is very clear and easy to understand, especially with the supporting pictures.
  • I dont know what the point of the gallery at the bottom is, those pictures would be more effective put throughout the page.
  • Glossary needs to be added to, every scientific word should be explained here, also should be listed alphabetically.
  • The diseases headings should be bolded more and maybe use some dotpoints in this section to make it easier to read, or put it in a table.
  • Overall, good project headings and pictures.


Synaptic Junctions:

  • Introduction needs to be gone over to correct minor grammatical errors, and problems with sentence structure.
  • History section need citations!
  • Listing components of synapses in main body and the diagram is redundant.
  • Chemical Synapse diagram not labeled.
  • I was confused by the last sentence of "What is Synaptic Junction?" about fast and slow acting neurotransmitters, try to make this clearer.
  • In "Synaptic Integration and Modulation" the introduction about integration and modulation wasn't clear to me. What exactly are they?
  • Overall, good balance of text, images, and tables. You guys gave a lot of other information which helps put synaptic junctions into context which is good. Mostly the text is easy to understand, but I would recommend reading it over again to see if some parts could be made clearer.


Group 1

Good choice for initial picture. Introduction could include a little bit more about what you will talk about.

History is too short and everything should be referenced. More research should be done to find out more recent findings.

Hand drawn pictures are lovely and complement the project very nicely. Obviously a lot of time was put into these, nice work!

Types of synaptic junctions is very concise.

Good balance between text and pictures in synaptic integration and modulation.

The use of tables allows for clear understanding.

Diseases are well researched, however they are very detailed and seem to be form a pathological perspective. Summarizing these and just putting the main relevant points could help.


GROUP 1: Synaptic Junction


This page caught my attention as soon as I saw it and that made me want to read on and thus learn about Synaptic Junction. A lot of research has gone into this assignment and it’s evident in the information presented as its precise which also helps capture the readers. The amount of research is also evident in the long list of references. The webpage is actually extremely informative covering pretty much every aspect of synaptic junction. Your webpage has the most pictures and this helps it stand out as one of the best project pages. I really, really like the formatting and the tables. The images break up the information so you’re never overloaded with the amount of text. The language in is the right mixture of scientific language meaning that even people without a scientific background can understand the junction. I also really like the first picture you have, give a page a really good feel to it.


Group 1

While I thought it was smart of this group to start with a brief understanding of the CNS, They wrote a full paragraph on the CNS without using a single reference. It shouldn’t be assumed that information about the CNS is common knowledge. Also, I may be wrong but I don’t think that synaptic junction should be capitalized every time it is written in the introduction. The groups’ history of synaptic junction ends in 1981. I’m sure that there have been important points on synaptic junctions that have came about in the last 30 years. The first sentence of “What is a Synaptic Junction” is very unclear and ahs grammar mistakes (to should be two). I would advise that this whole paragraph be re read to make clearer as there are a few sentences where the word “is” is used instead of “are”. Also, all 3 references for this section are placed at the end of the paragraph but I think that if a person looking at this page wanted specific information on one of their points, it would be easier for that person to access if they referenced immediately after the specific point. This is a thing that I noticed in the section “Types of Synaptic Junctions” as well. I liked the use of the schematic sketch (in the “What is a Synaptic Junction” section) to illustrate the synaptic junction. I found it made the paragraph easier to understand. The electrical and chemical synapse pictures that the student drew are really great and creative. I find it really cool that someone was able to draw these so well. One suggestion that I have that may make the page clearer is to possibly bold some important parts of the text. For example when the page mentions that the synapse has two key parts, I would then say to maybe make axon terminal and receptive region in bold to make them stand out more. In their table, I believe that gap junctions carry more than just ion current. There is no copyright information for the picture labelled “Steps of Transmission in Neural Networks”. I like the use of tables by this group. It helps summarize many paragraphs. There is no copyright information for the picture labelled “Proposed Model for the voltage dependent calcium channels”. I found the section on synaptic integration and modulation very well done and easy to understand. The image “Neurotransmitters” is missing reference information. Also, most of the section “Neurotransmitters” has no references whatsoever. It is a bit confusing in the disease section when it switches from Parkinson’s to Myasthenia Gravis. I know this is a formatting issue but I figured I would mention that they should make it clearer that they are addressing a new disease. Overall this was a clear project but there are certain grammar issues as well as referencing issues that need to be addressed.

Group 1

  • I like the fact that you give a brief overview of the nervous system in the introduction, so that the reader better understand your topic.
  • I like the history section as it is not too long, but informative, but maybe you can add some newer finding in this section.
  • Don’t forget to take out your name of the section you completed.
  • In the neurotransmitter section second sentence just fix the word chemical s, where there is an extra space between the L and S. So it will be a good idea to go over the whole assignment again and check grammar and spelling.
  • Good use of a table to explain the types to neurotransmitters.
  • The disease section is a bit long compared to the rest of the assignment, so there is probably some information missing in the other sections.
  • Your glossary would be easier to read if it was in alphabetical order.
  • Finally the gallery should be in the discussion page.


Group 1: Synaptic Junction

•Introduction should introduce what will be discussed on the rest of the page more clearly

•The history looks good but is there any current research you could add?

•The glossary needs to be added to and needs to be in alphabetical order

•The disease section is very long perhaps simplifying it and relating them more to your junction

•The table of neurotransmitters is excellent, try something like this for diseases so its easier to read and understand

•Use subheadings for types of junctions the text seems all integrated

•More research is needed on function of your junction

•Check grammar and spelling

•Remember to reference the project before the due date

•Drawings are great I think the text needs to simplified and integration of pictures will help readers understand the topic better


Group 1

Intro - It would be better if the introduction is broken up for easier read

History - Great!

What is SJ? - The elaboration of the components of the SJ would allow for better understanding

Type of SJ - Outlining where they are located and their actions in those locations would be good

modulation - What is the effect of modulation? neurotransmitters - Good use of tables! allows for easy read

Diseases - good! the layout is good however making the titles of the disease more distinct would be good. If you quickly scroll down on this section you dont really know what disease youre talking about.

Current and future research - More potential research studies would be good

Glossary - Alphabetically rearrange

Overall, good site just need to elaborate on some of the points you mentioned. Good work!


Group 1

  • Introduction:it basically just briefs through the 2 classes of nervous system , and not about the topic which is the synaptic junction. So , it kind of off the topic a little and lacks of intro info for this topic.
  • History: it is alright.
  • What is a tight junction: this is the introduction. This part should be at the top of the page, you guys might want to consider move this part to the introduction, and remove the one currently at the top, as it does not really help with understanding , not to mention the points of it are irrelevant if u think it through .
  • Types of tight junctions: Subheading classification would be more appropriate,just so readers can get started easily.

The text within the diagram key of the first image is too blurry and maybe little as well.

  • Synaptic regulation and modulation: Subheading roles would be more appropriate, the hand drawn image in this part looks blurry and does not show the features clearly.The third image of this part has the same problem as the previous one.
  • Neurotransmitters: A few electron or some other microscopy micrographs would be better.
  • Diseases associated and research: They`re both well done.
  • Glossary: The terms should be in alphabetical order.
  • Overall: there a few typing errors and images are unclear.


GROUP 1 REVIEW

  • Introduction: More info about what you are going to talk about
  • History: Good and to the point though is there something more recent(Only some points have full stops others do)
  • What is a Synaptic Junction:The pictures need likes to the site they came from and maybe extend the caption that says 'Em Synapse' to at least capital EM as it took me a while to understand what you were saying.
  • Types of Synaptic Junctions: Nice comparative table and images
  • Synaptic Integration and modulation: Well researched
  • Neurotransmitters: Excellent Table
  • Disease: The actual headings of the diseases, Parkinson and Myasthenia Gravis, gets lost in the writing which makes it confusing when reading. Also maybe a bit too much pathological and epidemiology on the topic, Maybe make this into a paragraph about the disease rather than so many subheadings.
  • Current and Future Research: Maybe add some links in to current research being done.
  • Gallery: Make sure ALL the images on the page are in it.
  • Glossary: You just need to Alphabetise this.


Group 1 Peer Review

  • The good thing about this project is the table of the neurotransmitters.
  • The picture is a good opening but the intro doesn’t introduce the topics that are covered.
  • History is not referenced so it make difficult to verify or know more about the historic research itself.
  • There is no information about the proteins involved/cell that make this structure
  • The diseases were explained as a pathology format which loses a bit connection. Should be more focused on what happened in this junction, what genes are involved in the abnormalities of this junction.
  • More research needed to complete the function part and what is important about this junction.
  • Some grammatical errors are here and there.
  • Drawings look good.
  • Glossary need some work
  • References need to be added.
  • Overall, the text needs to be simplified and balanced with the pictures. This will help the reader for a better understanding of this junction.


Group 1 Peer Review

  • Introduction should briefly describe the overview of what is going to be discussed throughout the page.
  • There should be some recent 20th century discoveries included in the history since the history stops at 1981.
  • The hand drawings are well drawn and amazing.
  • The table on neurotransmitters is very visual, and informative and straight to point. Love the colour coding!
  • The explanation on what is synaptic junction should be more simplified and easy to understand since I feel like there are a lot of terms and I got lost in the words.
  • Diseases associated with synaptic junctions is well done in a way that the diseases are not briefly described but includes the causes, epidemiology, pathogenesis, clinical presentations, etc which shows great research and understanding.
  • Overall, the images and texts balance out but it would help the reader to understand more about synaptic junctions if written in more simplified version.


Group 1:

  • Love your initial picture, it really captured my attention and wanted to make me read more about synaptic junctions.
  • I also loved the cancer cell picture and the student (Z3284061) drawn image. Obviously alot of time and effort went in to draw it! :)
  • The first thing i noticed was that there are no references in your history section, where did you get this information?
  • It also finishes a bit early, maybe try to find history up until around 2005.
  • Also there are missing references in the neurotransmitters subheading.
  • The current and future research section is really short.. are there any other future or current research topics you could cover? *There are are a few spelling errors, just do a quick spell check.
  • Glossary is really short, eg what is the Edrophonium test?


Group 1- Synaptic Junctions

  • Some of the sentences are long, and make it difficult to understand. I find myself lost when trying to read it.
  • I personally have not looked into the history of research on synaptic junctions, but i find it interesting that you have nothing after 1981. I am sure that there has been significant research since this time and maybe some more should be added, just so we can get a feel of what recent research is like. I know that you have a research methods section later on but I’m not sure this is sufficient.
  • In the “What is a synaptic Junction” section, the list of components in the image is a different order from the list in the image itself. I know this is a small thing to pick at but it just helps in understanding, and creates flow between text and image.
  • There is alot of information about WHAT the synapses are, but I feel like there isnt much on how or why. I think it would be more beneficial to describe the processes (in dot points) so that we can understand what is is doing, rather than what it is.
  • When I click on “axo-axonic synpase” it goes to an editing page?
  • The hand drawn images are amazing.
  • The tables make the information very clear. I understand the content well and it is visually appealing.
  • It is very impressive that you have gone into so much detail about the diseases. As a student who studies such processes I did find this interesting. However, by the end of it I was a little bit tired. I feel as though there is a focus on the diseases and neurotransmitters rather
  • Grammar and spelling errors are found throughout. This is a minor issue and can be fixed easily.
  • Overall your project is interesting, and for the most part easy to understand. I did at some points find that there were sections missing, such as function, but when I read further, I found some bits spread throughout.
  • Good work, good luck with the rest of the work to be done.


Synaptic Junctions

  • Some gramatical errors under “what is a synaptic junction”
  • What happens at each part of the synaptic junctions? Ie what happens at the synaptic cleft?
  • Need the basics before getting into different types of junctions ,
  • Lots of good information in “types of synaptic junctions” section, but there are many points without much elaboration. For example, if you mentioned two or three important discerning features of electrical synapses, it would be easier to read that 10 different points and minimal explanation
  • The chemical synapses section is a lot easier to read, if you follow a similar path for the electrical synapses (how not only what) it’d show your effort a bit better.
  • The links for ‘other synapses’ don’t lead to anything
  • Good table, it is succinct and information but regulated your use of capital letters
  • Need a section to explain function before getting into modulation and regulation, where they’re present etc (everywhere I know, but it would make it clearer to state it)
  • In ‘synaptic regulation and modulation’ section, the following paragraph doesn’t make sense – “Graded potentials can vary in size because they depend on the amount of neurotransmitter releasedThis is achieved through the regulation of free calcium inside the cell[16]. Axoaxonic synapses control calcium influx into the presynaptic terminal of . If more neurotransmitters bind to receptors, the amplitude of the depolarization increases. Summation to threshold can occur in two ways, or a combination of these two ways;”
  • Need to explain what axoaxonic synapses are
  • Neurotransmitter table looks really good
  • The abnormalities section looks really good and detailed, lots of information there
  • Fantastic pictures that have been drawn, they look really good and concise
  • There seem to be lots of spelling errors and gramatical errors throughout, I suggest you go through the whole thing and do a quick edit


Group 1- Synaptic Junctions

  • Watch the syntax in intro, history, what, types, and current research. Difficult to read
  • History section is not referenced
  • “receptive region” is not defined, making it difficult to understand the difference between chemical synapses and the list of synapses below
  • I’m not sure that the table summarising electrical and chemical synapses is necessary, because it is difficult to understand unless you read the text anyway.
  • Integration and modulation – worded well to aid readers understanding. Pictures are relevant and enable better understanding
  • Neurotransmitters- Grammar could be improved. Sentences don’t flow. The table is helpful, but I wonder if the “abnormalities” column would be better left out and the info placed in the disease section
  • Disease- interesting and well written. Some terms could definitely be included in the glossary e.g. “Substantia nigra”, “rostral midbrain”, “Superior Colliculus”. The link between Synaptic junctions and how dysfunction can cause disease is not well addressed
  • Excellent images throughout- attractive and informative

Group 1 Synaptic Junctions

  • Intro

Awesome picture to start off with. Scientific art has come along way. Its a great idea to visually capture the audience right away. Introduction is good but might benefit from a simplification review just to not lose the momentum generated by the outstanding first picture.

  • History

is well presented. Good emotive picture. clear time line

  • Function section more comprehensive outline
  • good use of information all round, however I feel a pairing down content could be useful
  • The project absolutely shows a superior integrity of group interaction.
  • a visible amount of research is evident that shows this group has researched their topic
  • Neurotransmitter Table is very clear and the teaching strategy of this worked for me
  • Disease etiology right up is outstanding and picture of

Edrophonium test for Myasthenia Gravis is briliant.

  • a few spelling typos and grammar
  • references need to be finalised
  • overall this does follow the idea of the wikipage as a teaching tool for synaptic junctions


Group 1: Synaptic Junctions

Introduction: Commas are used too frequently. Instead some sentences could be broken into two for an easier, more fluid read. Examples include, 'Neurons are a specialised cell which form the network of nerves, spinal cord and brain and will be explained in detail, how they play a key role in electrical signalling, later on.' and, 'Without Synaptic junctions, information and signals cannot be transmitted to areas of the body, its structure, mechanics dysfunctions and current related topics will now be explored in detail.' However, the general information and outline of what is to be be discussed is very clear.

History: A few entries about more recent research/discoveries may be able to give the reader a brief idea of where the field is progressing to.

What is: It would be helpful for the reader if a short explanation or a link to the glossary is given for each of the components listed for reference to the sketch.

Types: This section is clear both in terms of the layout of information (tables, diagrams etc.) and the content given.

Integration and modulation: This section extends on the previous entry very smoothly.

Diseases: The disease headings could be in a larger font so that they can be more quickly identified.

Gallery: The information about adding and sharing pictures could be placed on the discussion page as a reminder, as it detracts from the professionalism of the page.



Hey guys .. great work .. yayy !! everything is looking much better now .. :) thank u everyone ... xoxo--Navneet Ahuja 01:43, 12 May 2011 (EST)

hey guys its looking good! try to fill up the glossary a bit more, otherwise I cant think of anything else to add besides that =D --Mark Woods 22:13, 11 May 2011 (EST)

Hey guys, its looking gud.. can anyone think of any last minute inclusions before peer review? nice work guys =)--Mark Woods 00:38, 11 May 2011 (EST)

Hey .. lol awesome mark .. !! and i have neuro anat essay due on fri and my cofa thing due tonight .. but seems like everything is coming together now !! yayy .. good work everyone .. Meedo = L-O-V-E ur hand drawn photo !! seriously its gorgeous !!! ... if u want we can even use that for the group profile page .. its very nice .. worth waiting for hehe .. as for nathan .. i think the intro you uploaded is not here ?? I remember u telling me u already posted it up .. but its not appearing ? can u reupload ?? !! GREAT work guys .. !! i love our team !!!!!!!!! xoxo --Navneet Ahuja 21:54, 10 May 2011 (EST)

fair enough nany great work, ill fix up mine with references and adding to the glossary tonite =) wat other assignment do u hav? --Mark Woods 22:27, 9 May 2011 (EST)

hey guys ... i think its time to upload the rest of the photos and the introduction ?? its due this thursday for peer assesment and right know its still incomplete..plus the glossary is still very empty .. i will try to add more words but if u guys come across some special words in your own sections please add them in .. i am just a little worried about the page since i wouldnt be able to do anything on weds night with another major assignment due .. :) .. thanks guys ..xoxo --Navneet Ahuja 17:17, 9 May 2011 (EST)


Hey guys .. i have just added the current research part with a pic .. i am not sure if its ok ? can somebody read through and let me know ?? i am a little lost lol .. thanks guys .. :) --Navneet Ahuja 21:27, 8 May 2011 (EST)


ah yea now i remember, il organise some of the stuff ive already got for future research =) --Mark Woods 23:02, 4 May 2011 (EST)

hey all, im putting my stuff up tonight but im on a mac so my pictures wont be up til i can get on a windows with paint lol. Also ive got some future research stuff so ill do that part...but wernt we all gonna add something to it?--Nathan Weller 21:42, 4 May 2011 (EST)

I went through library textbooks =) i realise these ones are a little dull, perhaps ill replace them with more colourful ones after the perr assessment.. isnt nathandoing future research? nany, how bhout doing the intro? that counts as a section lol we wanted to save it til last just to c how our page wud look. wat do u think?--Mark Woods 17:13, 4 May 2011 (EST)

Hey guys .. I was thinking that the 2 left over sections should be spliited up between me and nathan since both of u had already done 2 sections each and i dont mind doing the current research section .. !! I just hoped we divided the sections earlier - otherwise .. good work guys and yes mark i do love ur photos .. where did u manage to find these from ??!! :P --Navneet Ahuja 15:05, 4 May 2011 (EST)


Hey Guys,

I'm happy to do introduction " simple version" then we can modify it or play around from your own sections!

But I'm not sure about the Development and current research! --Maqdad Al Saif 15:01, 4 May 2011 (EST)

hey guys, ill upload pictures of my section later today. Check it out, it goes fairly in depth and I tried to keep it simple but a lot of it seems pretty technical. Let me know if it's too much for the peer level, the pictures and stuff in my section will reinforce what is written.. I can change if necessary of course. Also, who wants to do the intro? :P --Mark Woods 10:14, 4 May 2011 (EST)

Hey .. I am a little confused with that one too .. but i think what he said today was we need all the content up and if the references is giving us trouble (computer hang) then we can slowly fix it later .. as for when its due .. (in the announcement it says next week but is it only for groups that is finding difficulties in ref ?? i am not entirely sure .. I like what meedo said of having a photo in each section and i have just added mine .. well i edited the photo (since the lisence allow me to) and labelled the key structures .. anyways I also added one funky image in the gallery its called "stained neurons" !! :)

meedo i was reading through ur section and loved it .. but i thought

"the nerve impulses are conveyed through the action of what is called neurotransmitters including " is it better to say conveyed "through chemicals or Chemical actions " since neurotransmitters are simply chemicals molecule but if you like it the way it is then its fine with me too :P --Navneet Ahuja 22:22, 3 May 2011 (EST)

do we need references completed for the peer assessment?

Hey guys .. AWESOME WORK !!! lol .. really loved the history section .. may be a "history timeline" but .. i read through all of them and like what meedo said .. its easy to understand .. !! and of course we could have both the gallery and pictures through out the page .. i just thought its going to be just in the gallery .. sorry for the confusion .. and history must have involved huge amount of research ??!! great work mark !! .. Ohh and as for the your part .. i liked it and i think it is related to synapse like what you said .. you need to explain about action potential before you can start talking about the release of neurotransmitters !! Ohh and nathan .. - i know i told you its due next week but as the announcement says .. i think we should try and finish everything as soon as possible ?? everyone think so ?

As for meedo .. dont worry about it .. ur section looks awesome .. love the background research !! --Navneet Ahuja 21:12, 3 May 2011 (EST)


no worries meedo! ur sections are looking gud, the writing style is very effective if this page were an educational tool =)

Ok guys, I want u to check out the first half of my section. A lot of this is outlining in a basic way how the nervous system works and y. Let me know what you guys think bout it, it felt weird writing stuff not directly linked to the synapse lol but i felt it is still important in understanding their function.--Mark Woods 20:27, 3 May 2011 (EST)

Hey Guys, sorry for being out of touch! Since i got problems uploading my things mainly due to my internet connection and my references... Mark, I like the simplicity of the history--> easy to read and straight to the point! after we add up all things together we can have a look at the overall process and whether additional historical information will be useful or not :)

and for the images, I agree with the idea of leaving an illustrative picture beside the text of the disease! " that way we can picture it in our heads" but I reckon having at least one image for each section will look better and less boring. what do you guys think?

As for me, I will upload some EMs and my sections will be filled! and my own drawings... If there's any comment or a need for adjustments, please feel free to do so and make a note that it has been changed.

Hope to see some awesome Synaptic junction page :D --Maqdad Al Saif 18:34, 3 May 2011 (EST)


hey guys what do u think of the history? i kept is breif and stuck to the main events, I don't think this section should take up too much space on the page, but there's still other events that did take place which I could include. --Mark Woods 18:03, 3 May 2011 (EST)

Good point Nany. And ur rite, images should be throughout the page as per usual, so don't let the gallery throw you off! I was hoping the gallery would be a place for addional images and such. Also, I don't see a problem with using an image in a section and having it also available in the gallery, what do u guys think? --Mark Woods 11:27, 3 May 2011 (EST)

I loved the images mark !! .. and I am going through the images too .. as for nathan .. my "abnormalities" section already mentioned all the diseases so you can just find a couple of article with images to go with some of the diseases listed .. hope that makes it easier .. and guys i was thinking should all the images be in the gallery ?? I think esp for the disease section it should be right next to the diseases .. like .. text on the right hand side and images on the left ?? what do you guys recon ??!! but good start mark .. :) xoxo --Navneet Ahuja 08:32, 3 May 2011 (EST)

hey guya, worked out the gallery lol. sso when u add an image, type Image:file name|what name you want to appear --Mark Woods 02:08, 3 May 2011 (EST)

Nathan, i found this on Pubmed for alzheimers; http://www.ncbi.nlm.nih.gov/pubmed/16273023. Could be useful --Mark Woods 16:30, 2 May 2011 (EST)

Hey Nany, hav u come across any images for the gallery? we're thinking EMs, diagrams, just a bunch of helpful pics n vids. I don't think we've set up the gallery yet, but when we do we can add to it before and after peer assessment, so keep that in mind =) --Mark Woods 15:03, 2 May 2011 (EST)

Hey mark .. i totally agree with the position of the title .. i think synaptic integration comes before neurotransmitter and very happy for u to change .. !! as for nathan - i am glad its almost done .. cant wait to see it .. and i agree with nathan that we all should start putting up resources for the current studies as well as photos .. i tried finding images but seemed like i have to look through them again during this weekend.. !! anyways .. as for the meeting .. did i miss out on anything ??!! and if u guys need any particular help on any sections .. please do not hesitate to let me know .. xoxo--Navneet Ahuja 19:45, 30 April 2011 (EST)

nice nathan. hey meedo, how in depth are you going to go into the function of the types? If not a lot, I can use my section to go into a fair bit of depth. What do you think? --Mark Woods 10:03, 30 April 2011 (EST)

hey just wanted to say good work yesterday, everythings starting to come together now. My diseases part is almost done and should have it up by the end of the weekend. everyone by due date try and add some things to the new research part if you can. --Nathan Weller 12:47, 29 April 2011 (EST)

nice work nany =) i switched around our sections, so synaptic integration comes before neurotransmitters, is that okay? I figure it makes more sense since I'm going to be talking about the presynaptic action potential, before neurotransmitter release.

--Mark Woods 11:42, 29 April 2011 (EST)

Hey there .. i just wanted to tell you guys i added a little tiny bit of glossary just to get it started .. !! lol I think its relevant to my section and will keep adding it once i find more info .. !! And thank u mark for letting me know the due date .. I thought it was on the 1st of May !! anyways .. hope u see u guys real soon .. xoxo--Navneet Ahuja 21:36, 26 April 2011 (EST)


hey nany, hope ur break is going well :) great work with the neurotransmitters section.the rest of us are planning to meet up on thursday to do some project work. the peer review is due the thursday of the week back, so we need the bulk up by then!

--Mark Woods 19:03, 26 April 2011 (EST)

Hey again guys .. I already did my part which is the neurotransmitters (although some of the references are missing .. i will slowly add them up !! Lol ..) please feel free to add or delete anything up there..!! I just realized i will be missing the group meeting .. please update me here of whats going on .. sorry again guys for not being able to attend the meeting .. and if you need my help for anything just post them here .. i promise to check it regularly lol!!! xoxo --Navneet Ahuja 03:49, 26 April 2011 (EST)


hey guys .. i saw that my section is neurotransmitters .. am more than happy to do it !!! I will totally keep in touch and start adding on my parts little by little .. sorry for not being there at todays lab though !! (hope i didnt miss out on alot??) anyways .. just letting you guys know great work with the subheading !!! Laslt, does anyone know if when this is due ? is it still on the 1st of May ? cya soon guys ... !!! xoxo --Navneet Ahuja 12:31, 21 April 2011 (EST)


Ok so those subheadings work;

1) Introduction

2) History? --> although I'm not sure if that's easy to find! however if it's important to be included, why not?

3) what is synaptic Junction? a different pictures

4) types of synaptic junctions! Table is essential + images to demonstrate the difference between types!

5) Neurotransmitters??

6) Synaptic integration

7) Diseases associated with synaptic junctions dysfunctions--> pictures needed!

8) Current and future research and developments ( where it's aimed, potential medical applicaitons)

9) Gallery (pretty much just thumbnails showing a whole lot of images we've come across. Will help ppl with visualizing)

10) Glossary

--Mark Woods 10:43, 21 April 2011 (EST)

Hey Guys,

Let me start by Saying that a Proper meeting would be great to See what parts we are going to write about. Since I find it a little difficult to see comments about neurotransmitters or types of synaptic junctions. I reckon it would be wonderful if we meet up and write the outline of the project for a start. After all, we can get starting with an actual progress! I know all of us want to get a good grade for this subject and get the most out of it! Note: it's essential for the meeting to be prior the holiday :)

What do you guys all think? Sorry for all that, it's my first time doing online project and stuff, so my way is by actual meetings

Oh, and I like the idea of neurotransmitters + synaptic junctions types!

A simple Outline I see commonly is;

1) Introduction

2) History? --> although I'm not sure if that's easy to find! however if it's important to be included, why not?

3) what is synaptic Junction? a different pictures

4) types of synaptic junctions! Table is essential + images to demonstrate the difference between types!

5) Neurotransmitters??

6) Synaptic integration

7) Diseases associated with synaptic junctions dysfunctions--> pictures needed!

8) Future research or developments!

9) Conclusion


Hope that wasn't much for a start!

--z3284061 22:53, 20 April 2011 (EST)

a section on neurotransimmtters is a gud idea, theres plenty in this textbook i got which we can use as a starting point. Also, the book (Principles of Neuroscience 4th edition- Kandel) splits up synaptic junctions as either chemical or electrical. Here is a little from it's intro pages:

Two types of synapse, electricaland chemical. Chemical synaptic junctions have synaptic clefts , electrical synaptic junctions have gap junctions 176.

Electrical distance between pre and post synaptic cell membrances: Electrical is 3.5nm and chemical is 30-40nm.

Electrical transmission is graded and occurs even when the currents in the presynaptic cell are below threshold for an action potential. 178


I think it would be helpful in terms of a starting point to look for additional references, as well as a good reference itself. ALso, we should cover synaptic intergration and modulation by second second messengers. What do you guys think?

I'm also happy with being allocated any subheadings =)

--Mark Woods 20:11, 20 April 2011 (EST)


hey guys --i totally agree with mark that we gotta start splitting up and i think the types of neurotransmitters should also be included somewhere in the page and i am more than happy to do anything u guys assign to me but in particular - i dont mind doing this table thing !! I will be missing thursday lab but of course i will be in touch and like what i said .. i am happy to do anything and i guess we should really get started since the deadline is not very far away .. ?? do u guys think we should do the timeline too ??!! --Navneet Ahuja 00:06, 20 April 2011 (EST)


Okay guys lets start getting some stuff up. So should we divide up the subheadings and each work on one? Some of the sections seem bigger than the others, maybe the Role shud be included in the intro?

--z3254753 21:08, 19 April 2011 (EST)



Hey guys, realised my historic article probably isn't old enough. Here's another one from a fair while back

Pharmacology and Nerve-endings (Walter Ernest Dixon Memorial Lecture): (Section of Therapeutics and Pharmacology)

[1]



--Mark Hill 17:02, 30 March 2011 (EST) OK Group 1, No content has been added to either your discussion or project page. You were meant to have already begun looking into both the topic and references, pasting links on your discussion page. I will see you in the lab tomorrow to discuss whether you are having problems or are simply not doing the work. This search should get you started. Search Pubmed: Synaptic Junction



Hey everyone. I was doing some research on our topic but it will be so similar to one of the other pages being done. Have a look yourself before tomorrow and we should make a final decision in the lab if this is what we should do.--Nathan Weller 23:37, 30 March 2011 (EST)


Good Idea, we should make a final decision before we can start posting references. See you guys tomo --z3254753 00:14, 31 March 2011 (EST)

hey guys ... sounds good .. and nathan i think u put the content in the wrong page.. (its in group 2's page) lol .. :) --Navneet Ahuja 09:11, 31 March 2011 (EST)


I think Nathan has done a remarkable Job for a start :)... Well, we can re-adjust it and have a look at the previous projects for more enlightments.. Maqdad Alsaif




Hey guys i did research some articles and here are some of it --Navneet Ahuja 16:12, 2 April 2011 (EST)

1)Synapse Formation in Developing Neural Circuits - general discription on how synapse work !!

Abstract [2]

The nervous system consists of hundreds of billions of neurons interconnected into the functional neural networks that underlie behaviors. The capacity of a neuron to innervate and function within a network is mediated via specialized cell junctions known as synapses. Synapses are macromolecular structures that regulate intercellular communication in the nervous system, and are the main gatekeepers of information flow within neural networks. Where and when synapses form determines the connectivity and functionality of neural networks. Therefore, our knowledge of how synapse formation is regulated is critical to our understanding of the nervous system and how it goes awry in neurological disorders.

Synapse formation involves pairing of the pre- and postsynaptic partners at a specific neurospatial coordinate. The specificity of synapse formation requires the precise execution of multiple developmental events, including cell fate specification, cell migration, axon guidance, dendritic growth, synaptic target selection, and synaptogenesis (Juttner and Rathjen in Cell. Mol. Life Sci. 62:2811, 2005; Salie et al., in Neuron 45:189, 2005; Waites et al., in Annu. Rev. Neurosci. 28:251, 2005). Remarkably, during the development of the vertebrate nervous system, these developmental processes occur almost simultaneously in billions of neurons, resulting in the formation of trillions of synapses. How this remarkable specificity is orchestrated during development is one of the outstanding questions in the field of neurobiology, and the focus of discussion of this chapter.

2) Review: disruption of the postsynaptic density in Alzheimer's disease and other neurodegenerative dementias.

Abstract [3]

The most common causes of neurodegenerative dementia include Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). We believe that, in all 3, aggregates of pathogenic proteins are pathological substrates which are associated with a loss of synaptic function/plasticity. The synaptic plasticity relies on the normal integration of glutamate receptors at the postsynaptic density (PSD). The PSD organizes synaptic proteins to mediate the functional and structural plasticity of the excitatory synapse and to maintain synaptic homeostasis. Here, we will discuss the relevant disruption of the protein network at the PSD in these dementias and the accumulation of the pathological changes at the PSD years before clinical symptoms. We suggest that the functional and structural plasticity changes of the PSD may contribute to the loss of molecular homeostasis within the synapse (and contribute to early symptoms) in these dementias.

3)Recent research Early Events of HIV-1 Infection: Can Signaling be the Next Therapeutic Target?

Abstract [4]

Intracellular signaling events are signposts of biological processes, which govern the direction and action of biological activities. Through millions of years of evolution, pathogens, such as viruses, have evolved to hijack host cell machinery to infect their targets and are therefore dependent on host cell signaling for replication. This review will detail our current understanding of the signaling events that are important for the early steps of HIV-1 replication. More specifically, the therapeutic potential of signaling events associated with chemokine coreceptors, virus entry, viral synapses, and post-entry processes will be discussed. We argue that these pathways may represent novel targets for antiviral therapy.

4. Historical research ACTION OF ADRENALINE ON SYNAPTIC TRANSMISSION AND ON ADRENAL MEDULLARY SECRETION [5]

and lastly this article might be helpful to us old neurons




references

  1. Daniel A Colón-Ramos Synapse formation in developing neural circuits. Curr. Top. Dev. Biol.: 2009, 87;53-79 PubMed 19427516
  2. Yuesong Gong, Carol F Lippa Review: disruption of the postsynaptic density in Alzheimer's disease and other neurodegenerative dementias. Am J Alzheimers Dis Other Demen: 2010, 25(7);547-55 PubMed 20858652
  3. Kate L Jones, Redmond P Smyth, Cândida F Pereira, Paul U Cameron, Sharon R Lewin, Anthony Jaworowski, Johnson Mak Early events of HIV-1 infection: can signaling be the next therapeutic target? J Neuroimmune Pharmacol: 2011, 6(2);269-83 PubMed 21373988
  4. J MALMEJAC Action of adrenaline on synaptic transmission and on adrenal medullary secretion. J. Physiol. (Lond.): 1955, 130(3);497-512 PubMed 13278916


Hey guys,

I found I've covered a fair bit of relevant stuff in my lecture notes for another course lol. Maybe they could help us direct our research a bit. Speak more about it in person in the lab :)

here are my research articles;

Gray Matter NG2 Cells Display Multiple Ca-Signaling Pathways and Highly Motile Processes. - current research

[1]


The importance of sensory nerve endings as sites of drug action. - review article

[2]

Electrophysiologic evidence for an intersegmental reflex pathway between lumbar paraspinal tissues - historical research

[3]

--z3254753 12:48, 6 April 2011 (EST)

references

  1. Christian Haberlandt, Amin Derouiche, Alexandra Wyczynski, Julia Haseleu, Jörg Pohle, Khalad Karram, Jacqueline Trotter, Gerald Seifert, Michael Frotscher, Christian Steinhäuser, Ronald Jabs Gray matter NG2 cells display multiple Ca2+-signaling pathways and highly motile processes. PLoS ONE: 2011, 6(3);e17575 PubMed 21455301
  2. K H Ginzel The importance of sensory nerve endings as sites of drug action. Naunyn Schmiedebergs Arch. Pharmacol.: 1975, 288(1);29-56 PubMed 1099463
  3. Yu-Ming Kang, Woo-Sung Choi, Joel G Pickar Electrophysiologic evidence for an intersegmental reflex pathway between lumbar paraspinal tissues. Spine: 2002, 27(3);E56-63 PubMed 11805709


--z3254753 23:55, 5 April 2011 (EST) Hello Team,

After searching for a while, I came up with these related Articles--z3284061 20:35, 6 April 2011 (EST):

Historic Article:

Morphological changes in the neuritic growth cone and target neuron during synaptic junction development in culture


[1]

Current Research:

Turnover of synapse and dynamic nature of synaptic molecules in vitro and in vivo.

[2]

Review:

Synaptic next term structure and function: Dynamic organization yields architectural precision

*Note: Since this Article is not from Pubmed, I've added an external link.

references

  1. R P Rees, M B Bunge, R P Bunge Morphological changes in the neuritic growth cone and target neuron during synaptic junction development in culture. J. Cell Biol.: 1976, 68(2);240-63 PubMed 173724
  2. Satoru Kondo, Shigeo Okabe Turnover of synapse and dynamic nature of synaptic molecules in vitro and in vivo. Acta Histochem Cytochem: 2011, 44(1);9-15 PubMed 21448313



--Nathan Weller 00:24, 7 April 2011 (EST)

Review article:

To build a synapse: signaling pathways in neuromuscular junction assembly

Historical article:

Electron microscopy of the cerebral cortex. I. The ultrastructure and histochemistry of synaptic junctions.

Current article:

Ca2+ signaling in the regulation of dendritic cell functions.

References

Review article

To build a synapse: signaling pathways in neuromuscular junction assembly, Haitao Wu, Wen C. Xiong and Lin Mei*, doi: 10.1242/dev.038711 April 1, 2010 Development 137, 1017-1033. article link

Historical article

Electron microscopy of the cerebral cortex. I. The ultrastructure and histochemistry of synaptic junctions,DE LORENZO AJ., Bull Johns Hopkins Hosp. 1961 Apr;108:258-79. [1]

Current article

Ca2+ signaling in the regulation of dendritic cell functions, Am J Physiol Cell Physiol. 2011 Mar 30, Shumilina E, Huber SM, Lang F. University of Tuebingen.

[2]