Talk:2010 Lecture 4
- JCB - Involvement of the Lamin Rod Domain in Heterotypic Lamin Interactions Important for Nuclear Organization
- Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy
- A Comparative Study of Drosophila and Human A-Type Lamin
- Nuclear pore complexes are fixed in place Daigle et al. report that nuclear pore complexes (NPCs) undergo limited movements that match the deformations of the nuclear envelope as tracked using a grid of bleached nuclear lamins. NPCs are therefore remarkably stable complexes, and are probably anchored to a protein network in the nuclear envelope.
- Nucleoporins reassemble around post-mitotic chromatin A conserved nuclear pore subcomplex was characterized and tracked by Belgareh et al., who found that the proteins were recruited during telophase in a rim pattern surrounding the chromosomes. A low level of staining was also apparent on the kinetochores throughout mitosis.
- Nucleolar re-formation after mitosis Savino et al. follow the re-formation of nucleoli after mitosis. Prenucleolar bodies (PNB) form on the chromosome surface and nucleolar material flows along links between PNBs and towards a developing nucleolar organizer region (NOR). Eventually this leads to the fusion of nucleoli to form a single entity.
- Processing complexes may help reassemble nucleoli Nucleolar reassembly during telophase is shown by Dundr et al. to require mitotically preserved processing complexes.
- Speckles - A splicing factor has limited mobility Based on the limited mobility of a splicing factor, Kruhlak et al. determine that the factor undergoes frequent but transient interactions with relatively immobile nuclear binding sites, both when associated with speckles and when dispersed in the nucleoplasm. This a 3-D video that should be viewed using red/green 3-D glasses.
- Journal of Cell Biology (JCB) copyright notice extract "Beginning six months after publication, Rockefeller University Press grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode."