File:VCJD brain.png

From CellBiology
VCJD_brain.png(336 × 600 pixels, file size: 1.08 MB, MIME type: image/png)

Histological and immunohistochemical features.

A and B. The cerebral cortex is markedly disrupted with prominent astrogliosis and presence of amyloid plaques (arrows in B); frontal cortex; H.E. C and D: PrP immunostaining shows the presence of many plaques (arrows) and plaque-like aggregates in superficial and deep cortical regions with a punctate background staining; frontal cortex. E: Distinctive spot-like PrP immunostaining in the molecular layer and many plaques especially evident in the Purkinje cell layer of the cerebellum. F: Plaques, often in a row are present in the superficial white matter; cerebellum. C–F: Monoclonal antibody (mAb) 3F4.

http://www.plosone.org/article/slideshow.action?uri=info:doi/10.1371/journal.pone.0008765&imageURI=info:doi/10.1371/journal.pone.0008765.g001

Citation: Notari S, Moleres FJ, Hunter SB, Belay ED, Schonberger LB, et al. (2010) Multiorgan Detection and Characterization of Protease-Resistant Prion Protein in a Case of Variant CJD Examined in the United States. PLoS ONE 5(1): e8765. doi:10.1371/journal.pone.0008765

Editor: Delia Goletti, National Institute for Infectious Diseases L. Spallanzani, Italy

Received: October 19, 2009; Accepted: December 18, 2009; Published: January 19, 2010

Copyright: © 2010 Notari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008765

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current17:06, 9 March 2010Thumbnail for version as of 17:06, 9 March 2010336 × 600 (1.08 MB)S8600021 (talk | contribs)Histological and immunohistochemical features. A and B. The cerebral cortex is markedly disrupted with prominent astrogliosis and presence of amyloid plaques (arrows in B); frontal cortex; H.E. C and D: PrP immunostaining shows the presence of many plaqu
  • You cannot overwrite this file.

Metadata