Histological and immunohistochemical features.
A and B. The cerebral cortex is markedly disrupted with prominent astrogliosis and presence of amyloid plaques (arrows in B); frontal cortex; H.E. C and D: PrP immunostaining shows the presence of many plaques (arrows) and plaque-like aggregates in superficial and deep cortical regions with a punctate background staining; frontal cortex. E: Distinctive spot-like PrP immunostaining in the molecular layer and many plaques especially evident in the Purkinje cell layer of the cerebellum. F: Plaques, often in a row are present in the superficial white matter; cerebellum. C–F: Monoclonal antibody (mAb) 3F4.
Citation: Notari S, Moleres FJ, Hunter SB, Belay ED, Schonberger LB, et al. (2010) Multiorgan Detection and Characterization of Protease-Resistant Prion Protein in a Case of Variant CJD Examined in the United States. PLoS ONE 5(1): e8765. doi:10.1371/journal.pone.0008765
Editor: Delia Goletti, National Institute for Infectious Diseases L. Spallanzani, Italy
Received: October 19, 2009; Accepted: December 18, 2009; Published: January 19, 2010
Copyright: © 2010 Notari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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