2013 Revision

From CellBiology

Introduction

This revision lecture will be an opportunity for students to revise content from the course and cover any issues from the lecture material that is not clear. Please note there are no past exam papers available for this course.


Lecture Audio: Lecture 22 Audio Lecture Date: 2013-06-06 Lecture Time: 14:00 Venue: Matthews D Speaker: Dr Mark Hill

Course Assessment

There will be three parts to the course assessment.

  1. Independent Learning - Assessment throughout semester. 20%
  2. Group Project – An online project. 20%
  3. Theory - A written test held during the examination period. 60%

The theory exam is a 2 hour short answer essay format, assessing student understanding and comprehension of cell biology. Questions are based on lecture material and supporting laboratory content.


Theory Exam Structure

  • TIME ALLOWED - 2 hours
  • READING TIME – 10 minutes
  • TOTAL NUMBER OF QUESTIONS – 10
  • TOTAL MARKS AVAILABLE – 60
  • ALL QUESTIONS ARE OF EQUAL VALUE
  • ANSWER 6 QUESTIONS ONLY
  • ANSWER EACH PART IN SEPARATE BOOKS
  • ALL ANSWERS MUST BE WRITTEN IN INK. EXCEPT WHERE THEY ARE EXPRESSLY REQUIRED FOR, PENCILS MAY BE USED ONLY FOR DRAWING, SKETCHING OR GRAPHICAL WORK
  • PRINT YOUR STUDENT NUMBER AND NAME ON TOP RIGHT HAND CORNER AND SIGN
  • THE PAPER MAY NOT BE RETAINED BY CANDIDATE

UNSW Examinations

Links: UNSW Examinations | Exams at UNSW - essential information for students

Examination period: Friday 14 June to Monday 1 July Supplementary exams (SoMS): week commencing Monday 8th July, 2013.

Please contact the student centre if you were unable to attend the theory examination. The course coordinator is not the contact person under these circumstances.


Please Note - myUNSW will have a scheduled outage period on the weekend of the 22-23 June 2013. Print your exam timetable before the scheduled outage period.

ANAT3231 Theory Exam

Date: Saturday 15 June

Time: 8:45 AM - 11:00 AM

Location: Marquee F, Randwick Racecourse

Please check any schedule updates or changes on UNSW Examinations

Lecture Objectives

Cells Eukaryotes and Prokaryotes

  • Introduction to biological molecules
  • Understand the dimensions cells
  • Understand differences between prokaryotes and eukaryotes
  • Understand differences between unicellular and multicellular organisms
  • Brief understanding of viruses and prions

Cell Membranes and Compartments

  • Understand the concept of separate intracellular spaces
  • Understand the structure of membranes
  • Brief understanding of history of membrane models
  • Understand the difference between physical and functional compartments
  • Brief understanding of membrane specializations

Cell Nucleus

  • Understand the concept of the cell nucleus
  • Understand the overall structure and components within the nucleus
  • Understand the functions of the nucleus
  • Brief understanding of chromosomal structure

Cell Export - Exocytosis

  • Brief understanding of gene expression
  • Understanding structure and function of organelles and structures associated with protein export (exocytosis)
    • ribosome
    • endoplasmic reticulum
    • vesicles - types and transport
    • Golgi apparatus structure and function
  • Brief understanding of transport between secretory compartments
  • Brief understanding of membrane turnover

Cell Import - Endocytosis

  • Understanding of the process of endocytosis
  • Understanding structure and function of organelles and structures associated with substance import (endocytosis) including:
    • endosomes, lysosomes, peroxisomes, Golgi apparatus and endoplasmic reticulum
  • Understanding of other cell import mechanisms, phagocytosis etc.
  • Brief understanding of signal, viral and bacterial entry into the cell
  • Brief understanding of transport within the cell

Cell Mitochondria

  • Broad understanding of processes requiring energy within the cell
  • Brief understanding structure and function of plant chloroplast
  • Understand the structure and function of plant and animal mitochondria
  • Brief understanding of mitochondria evolution
  • Brief understanding of mitochondrial abnormalities

Cell Junctions

  • Broad understanding of cell adhesion with other cells and extracellular matrix
  • Understanding of different adhesion proteins
  • Understanding of different forms of adhesion junctions
  • Understanding of biological role of adhesion
  • Brief understanding of adhesion abnormalities

Cytoskeleton - Intermediate Filaments

  • Broad understanding of the cell cytoskeleton
  • Understanding of intermediate filament function
  • Understanding of intermediate filament structure
  • Understanding of intermediate filament proteins
  • Understanding of intermediate filament location in nucleus and cytoplasm
  • Understanding of intermediate filament adhesion junctions
  • Broad understanding of intermediate filament abnormalities

Cytoskeleton - Microfilaments

  • Understanding of microfilament function
  • Understanding of microfilament structure
  • Understanding of microfilament proteins and motors
  • Understanding of microfilament location and adhesion junctions

Cytoskeleton - Microtubules

  • Understand the structure and role of microtubules
  • Understand tubulin structure
  • Understand motor molecules of the microtubule network
  • Brief understanding of microtubule associated proteins
  • Brief understanding of drugs that effect microtubules
  • Brief understanding of microtubule role in mitosis

Extracellular Matrix 1 Extracellular Matrix 2 Content for these 2 lectures were combined as a single lecture for 2013.

  • Understand the localisation and origin of extracellular matrix
  • Understand the 3 major components - fibers, proteoglycans (matrix), adhesive glycoproteins
  • Broad understanding of structure and function
    • collagen fibers
    • elastin fibers
    • proteoglycans
    • fibronectin
    • laminin
    • basement membrane
  • Broad understanding of some key extracellular matrix experiments

Cell Cycle

  • Understanding of the main stages of the cell cycle
  • Broad understanding of different cell lifespan
  • Understanding of the differences between embryonic and adult cell cycles
  • Understanding of the key regulators of cell cycle
    • cyclins
    • cyclin dependent kinases
  • Broad understanding of abnormal cell cycles
    • How the cell cycle is monitored

Cell Division

  • Understanding of the main stages of cell division
  • Understanding of cytokinesis
  • Understanding of chromosome structure
  • Broad understanding of the differences between mitosis and meiosis
    • including sex differences

Cell Death 1 Cell Death 2

  • Understanding of the different forms of cell death
  • Understanding of the various forms of stress response
  • Understanding of apoptosis and necrosis

Signal 1 Signal 2

  • Understand main types of signaling mechanisms
  • Understand concept of receptor and ligand
  • Understand membrane, cytoplasmic and nuclear receptors
  • Brief understanding of steroid hormone pathway
  • Brief understanding protein growth factor pathway
  • Understand differences between select membrane receptors (G protein structure, tyrosine kinases)

Stem Cells 1 Stem Cells 2

  • Understanding of the different types of stem cells
    • embryonic, adult, inducible
  • Brief understanding of the history of stem cell research
  • Understanding of the advantages and disadvantages of embryonic vs adult stem cells
  • Stem cell factors and markers

Development

  • Understand the utility of model organisms in research on developmental mechanisms
  • Understand the conceptual importance of somatic cell nuclear transfer (cloning) experiments
  • Understand the concept of how lineage restriction is controlled by the expression of DNA-binding transcription factors
  • Brief understanding of how transcription factor expression can be controlled by signaling pathways
  • Brief understanding of cell movements in development
  • Brief understanding of how apoptosis can create shape



2013 Course Content

Lectures: Cell Biology Introduction | Cells Eukaryotes and Prokaryotes | Cell Membranes and Compartments | Cell Nucleus | Cell Export - Exocytosis | Cell Import - Endocytosis | Cell Mitochondria | Cell Junctions | Cytoskeleton Introduction | Cytoskeleton - Intermediate Filaments | Cytoskeleton - Microfilaments | Cytoskeleton - Microtubules | Extracellular Matrix 1 | Extracellular Matrix 2 | Cell Cycle | Cell Division | Cell Death 1 | Cell Death 2 | Signal 1 | Signal 2 | Stem Cells 1 | Stem Cells 2 | 2013 Revision | Development


Laboratories: Introduction to Lab | Microscopy Methods | Preparation/Fixation | Immunochemistry | Cell Knockout Methods | Cytoskeleton Exercise | Confocal Microscopy | Tissue Culture | Stem Cells Lab | Microarray Visit | Lab


2013 Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7

Dr Mark Hill 2015, UNSW Cell Biology - UNSW CRICOS Provider Code No. 00098G