and malfunction of microtubules.
dynamic instability of the building blocks of microtubules allows the tube
to break down and reform almost spontaneously. In cell motility, the alpha
and beta dimers combine in plasma membranes to become cilia or the
for transportation of vesicles from one organelle to another. But is most
important in mitosis, where they disassemble and form the bipolar poles in
the cell during interphase and allow for attachments of chromosomes. They
might even play a role in the terminal between metaphase and
is an important form of antimitotic drug used in chemotherapies to treat
cancers of the ovaries, lung, neck and head, bladder, and oesophagus.
Taxol aim for microtubules and cause polymerisation, stabilising the
proliferation of microtubules and suppressing the formation of polar
spindles. This also prevents the cell from progressing to anaphase.
Polymerisation stops the treadmill motion of the microtubules and inhibits
the dynamics of growing and shortening of the polymers, which make up the