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UNSW Cell Biology

2008 ANAT3231 Lecture 16-17 - Cell Death

Introduction

Cell death occurs by 2 processes Necrosis and Apoptosis. Unprogrammed cell death, Necrosis, leads to the bursting of a cell and its contents being spilled into the extracellular space, followed by inflammation. Programmed cell death, or Apoptosis (a term first coined in 1972), is a series of regulated steps modification of cell membrane, DNA condensation and severing, cytoskeleton dissassembly, followed by "blebbing" cytoplasmic and nuclear contents into membrane bound fragments, engulfed by macrophages.

Cell Death is a field of research that has grown enormously in recent years. The growing interest is not only for its biological relevance in maintaining homeostasis in multicellular organisms, but also for its potential clinical application in regulating cell numbers (both up and down).

These lectures introduces Cell Division, current slides are now linked below.

Lecture 16-17:

PDF 2008 lecture16-17 1 slide/page (view)

PDF 2008 lecture16-17 4 slides/page (print)

PDF 2008 lecture16-17 6 slides/page (print)

PDF 2008 lecture16-17 slides text (print)

 

Page Links: Introduction | Objectives | Lecture Audio | Textbooks | Abnormalities | References | Online Textbooks | Web Links | Web Movies | 2007 Lecture Slides | Comments | Acronyms

Objectives

Lecture Audio

The University has a system for automated recording of lectures called Lectopia (or iLecture).

L16 Lectopia Recording | L17 Lectopia Recording

Top

Links: Lectopia Login Page | Cell Biology Podcast Page | Current Course Outline 2008

History

1887

Links:

Abnormalities

Links: NCBI - Genes and Diseases | NCBI - OMIM |

References

Molecular Biology of the Cell
Cells Die Tidily as a Part of the Program of Development
Image: cells dying by apoptosis
Regulation of Cell Survival Is as Important as Regulation of Cell Proliferation

Molecular Cell Biology
23.8. Cell Death and Its Regulation
Apoptosis Summary
Perspectives for the Future

The Cell- A Molecular Approach
Signaling Cell Survival Regulation of Programmed Cell Death
Image: Regulators and effectors of apoptosis
The PI 3-kinase pathway and cell survival

Online References

Listed links that relate to this Lecture from the textbook "Molecular Biology of the Cell" which is available free online. Note that this is the full version of your textbook "Essential Cell Biology".

Molecular Biology of the Cell (Ch22) "Apoptosis"

Listed links that relate to this Lecture from the textbook "Molecular Cell Biology, 4th edn" by Lodish, Berk, Zipursky, Matsudaira, Baltimore, and Darnell

Molecular Cell Biology (Ch23) "Apoptosis" Developmental Biology

Listed links that relate to this Lecture from the textbook "Developmental Biology, 6th Edn" by Gilbert which is available free online.

  • Developmental Biology (Ch6) "Apoptosis"

    Other Online PubMed Texts Search "apoptosis"

    The Cell- A molecular approach (Ch13) "Apoptosis"

    References

    Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Kerr, J. F., Wyllie, A. H. & Currie, A. R. Br. J. Cancer 26, 239-257 (1972)

    Apoptosis in the nervous system.Yuan J, Yankner BA. Nature. 407(6805):802-9 (2000)

    • Web Links

    Sigma Apoptosis Brochure

    Reproductive and Cardiovascular Disease Research Lab

    Web Movies

    Introduction to Genetic Analysis Introduction to Genetic Analysis. 7th ed. Griffiths, Anthony J.F.; Miller, Jeffrey H.; Suzuki, David T.; Lewontin, Richard C.; Gelbart, William M. New York: W. H. Freeman & Co.; c1999.

    Molecular Cell Biology

    First link is directly to Quicktime move, followed by associated textbook figure with legend. Look at the movie first, then look at the labelled image. Top

    Acronyms

    2007 Lecture Slides

    (MH - note that content will not match exactly current lecture structure but has been selected as having similar content)

    lecture07 1 slide/page (view only) (55 pages, 1.7 Mb)

    lecture07 4 slides/page (print) (14 pages, 932 Kb)

    lecture07 outline (print no images) (7 pages, 160 Kb)

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    Links: Download Acrobat Reader 8.0

    Related Topics

    Medicine BGD Apoptosis The first page of a series of 4 pages covering apoptosis for UNSW Medical students.

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    Comments

     

    In 2008 a new way of presenting course content online is being trialled. Please let me know of any difficulties/suggestions or things that work well.

    Notice also that in some slides I have added annotations in brackets with my initials (MH - )
     

    Links: Current Course Outline 2008