UNSW Cell Biology

2008 ANAT3231 Lecture 09 - Cell Cytoskeleton 1 - Intermediate Filaments

Introduction

This lecture gives a general introduction to the cell cytoskeleton and will be covered in a series of 3 lectures describing each of the filament systems. This first lecture introduces the intermediate filaments, their structure and function within the cell. There are many different types of cellular junctions that occur between cells and the matrix which surrounds them. This topic will be addressed again when we look at the cell cytoskeleton and the extracellular matrix. Lecture 9: PDF 2008 lecture9 1 slide/page (view) PDF 2008 lecture9 4 slides/page (print) PDF 2008 lecture9 6 slides/page (print) Lab 5: Immunochemistry

Page Links: Introduction | Objectives | Lecture Audio | Textbooks | Double Membrane Organelles | Chloroplasts | Abnormalities | References | Online Textbooks | Web Links | Web Movies | 2007 Lecture Slides | Comments Acronyms

Objectives

• Broad understanding of the cell cytoskeleton
• Intermediate filament structure
• Intermediate filament proteins
• Intermediate filament nucleus and cytoplasm
• Intermediate filament adhesion junctions

Lecture Audio

The University has a system for automated recording of lectures called Lectopia (or iLecture).

L09 Lectopia Recording

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Links: Lectopia Login Page | Cell Biology Podcast Page | Current Course Outline 2008

Physical Characteristics

• 10 nm diameter
• Named by relative size
• Provide rope-like resistance to mechanical stress
• in muscle- link Z discs of adjacent myofibrils

History

Abnormalities

Alexander Disease Pachyonychia Congenita Epidermolysis Bullosa Simplex Giant Axonal Neuropathy Epidermolysis Bullosa with Pyloric Atresia Dystrophic Epidermolysis Bullosa
Genes and Diseases http://www.ncbi.nlm.nih.gov/books/bookres.fcgi/gnd/tocstatic.html OMIM - Online Mendelian Inheritance in Man http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim

Links: NCBI - Genes and Diseases | NCBI - OMIM |

References

There is a complete list of online textbook links at

 

• Essential Cell Biology - Chapter

• Molecular Biology of the Cell 4th ed.
  • Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter New York and London: Garland Science; c2002
    • The Mitochondrion | Various sizes of mitochondrial genomes
• The Cell - A Molecular Approach -
• Cooper, Geoffrey M. Sunderland (MA): Sinauer Associates, Inc. ; c2000
  • Mitochondria

There is a complete list of online textbook links at 2008 ANAT3231 Lecture 07 - Cell Energy Production - References

• Molecular Cell Biology -

• Lodish, Harvey; Berk, Arnold; Zipursky, S. Lawrence; Matsudaira, Paul; Baltimore, David; Darnell, James E. New York: W. H. Freeman & Co. ; c1999
  • Mitochondria Are the Principal Sites of ATP Production in Aerobic Cells

• Mitochondria references

• Duchen MR. Roles of mitochondria in health and disease. Diabetes. 2004 Feb;53 Suppl 1:S96-102. Review.
• Brown GC, Bal-Price A. Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Mol Neurobiol. 2003 Jun;27(3):325-55. Review.
• Newmeyer DD, Ferguson-Miller S. Mitochondria: releasing power for life and unleashing the machineries of death. Cell. 2003 Feb 21;112(4):481-90. Review. Erratum in: Cell. 2003 Mar 21;(112)6:873.

Web Links

Web Movies

Molecular Cell Biology

First link is directly to Quicktime move, followed by associated textbook figure with legend. Look at the movie first, then look at the labelled image.

 

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Acronyms

• ATP - Adenosine Triphosphate
• DNA - deoxyribonucleic acid
• EM - electron microscopy
• FL - flourescent

2007 Lecture Slides

(MH - note that content will not match exactly current lecture structure but has been selected as having similar content)

 

See also Lecture Slides Text on this current page

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Links: Download Acrobat Reader 8.0

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Comments

 

	In 2008 a new way of presenting course content online is being trialled. Please let me know of any difficulties/suggestions or things that work well. Notice also that in some slides I have added annotations in brackets with my initials (MH - )
	Links: Current Course Outline 2008