Outside of the cell is the extracellular matrix (ECM). This matrix, even from a basic list of its components; proteins, glycoproteins, glycosaminoglycans, and many other large and small biological molecules, can been seen as complex. Furthermore there is no one specific ECM with great variation from tissue to tissue and also specific functional specializations. The lecture will attempt therefore to only cover a few key concepts on this topic.
The key concepts are: extracellular matrix, collagen, proteoglycans, fibronectin, laminin, basal lamina, basement membrane, adhesion, signaling, focal contacts, integrins
The lecture slides and textbook alone contain enough information as an introduction to the subject for this level of study. If you are interested in further reading, I have also included below links to more detailed textbooks with further information and images. Please note this additional information is not necessarily examinable, but may be useful if you have not previously studied biology. The link below to lecture slides allows you to open and view the slides in your web browser or download the PDF document for later viewing/printing.
Understand the role of the extracellular matrix
Understand the components of the extracellular matrix
Understand the structure and synthesis of collagen fibers
Brief understanding of proteoglycan structure and function
Brief understanding of fibronectin and lamin structure and function
Link to lecture slides allows you to open and view the slides in your web browser or download the PDF document for later viewing/printing.
lecture08 1 slide/page (view only) (43 pages, 1.8 Mb)
lecture08 4 slides/page (print) (11 pages, 620 Kb)
lecture08 outline (print no images) (6 pages, 156 Kb)
Molecular Biology of the Cell
Molecular Cell Biology
The Cell- A Molecular Approach
Search NLM Online Textbooks- "apoptosis"