UNSW Cell Biology

ANAT3231 Lecture 11 Signalling

Introduction

This lecture is an introduction to cell signaling. The lecture slides and textbook alone contain enough information as an introduction to the subject for this level of study. If you are interested in further reading, I have also included below links to more detailed textbooks with further information and images. Please note this additional information is not necessarily examinable, but may be useful if you have not previously studied biology. The link below to lecture slides allows you to open and view the slides in your web browser or download the PDF document for later viewing/printing.

Objectives

Understand main types of signaling mechanisms

Understand concept of receptor and ligand

Understand membrane, cytoplasmic and nuclear receptors

Brief understanding protein growth factor pathway

Brief understanding of steroid hormone pathway

Page Links: iLecture Audio | Lecture Slides | Lecture Slides Text | NLM Online Textbooks | Search PubMed | Web Links | Movies | OMIM Microfilaments | Related Topics

iLectureAudio

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2005 Lecture 11 Cell Signal 1
2005 Lecture Series

Lecture Slides

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See also Lecture Slides Text on this current page

Laboratory 10

The associated Laboratory 11 will focus on Lab Project work in G2/G4.

NLM Online Textbooks

Molecular Biology of the Cell

• Below are listed links that relate to this Lecture from the textbook "Molecular Biology of the Cell" which is available free online. Note that this is the full version of your textbook "Essential Cell Biology".
• Molecular Biology of the Cell (Ch22) "Cell Signaling"

Molecular Cell Biology

• Below are listed links that relate to this Lecture from the textbook "Molecular Cell Biology, 4th edn" by Lodish, Berk, Zipursky, Matsudaira, Baltimore, and Darnell
• Molecular Cell Biology (Ch23) "Cell Signaling"

Developmental Biology

• Below are listed links that relate to this Lecture from the textbook "Developmental Biology, 6th Edn" by Gilbert which is available free online.
• Developmental Biology (Ch6) "Cell Signaling"

Other Online PubMed Texts Search "cell signaling"

• The Cell- A molecular approach (Ch13) "Cell Signaling"
• Annual Reviews Collection "Cell Signaling"

Textbooks

Histology and Cell Biology (Kierszenbaum): Chapter 3. Cell Signaling

Online Teaching Sites

(links to a number of different online educational resources)

• The WWW Virtual Library of Cell Biology- Signal Transduction
  • Growth Factors, Cytokines and Trophic Factors
    • Cytokines Online Pathfinder Encyclopaedia - Pages covering all aspects of cytokine research.
    • Cytokines Web - Information about cytokines and their receptors, including 3-D structural information and topological and evolutionary relationships
    • The Growth Factor and Cytokine Page - Information on growth factors and cytokines.
    • Neurotrophic Factors - A collection of pages relating to the structures of neurotrophic factors.
  • Receptors and Signaling Effectors
    • Activation of the EGF Receptor Kinase - Molecular model of epidermal growth factor (EGF) receptor activation.
    • The Calpain Family of Proteases - Information on calpains, calcium-dependent cytosolic proteases involved in signal transduction.
    • The EF-Hand Calcium-Binding Proteins Data Library - "A growing collection of published sequence, structural, functional, and other information about EF-hand calcium-binding proteins and their roles in cellular signal transduction." (Melanie Nelson, Physiome Sciences)
    • The G-Protein-Coupled Receptor Database (GCRDb) - Database on G-protein-coupled receptors.
    • GRAP Mutant Database - Database on G-protein-coupled receptors and their mutants.
    • Heterotrimeric G-Protein Signaling - Overview of G-protein-coupled receptors, G-proteins and downstream effectors.
    • MIT Biology Hypertextbook: Receptors - Tutorial on transmembrane receptors and signaling cascades. (Beginner's Level)
    • The Nuclear Receptor Resource - A collection of individual databases on members of the steroid and thyroid hormone receptor superfamily (such as glucocorticoid, androgen, thyroid hormone and mineralocorticoid receptors).
    • The Olfactory Receptor Database (ORDB) - Database that "aims to house all of the known olfactory receptor and chemoreceptor sequences in both nucleotide and amino acid form." (Yale University)
    • The Protein Kinase Resource - A compendium of information on protein kinases.
  • Specific Pathways
    • Mammalian MAPK Signalling Pathways - Image map depicting major components of MAPK pathways. (Woodgett Lab).
    • Synaptic Transmission: A Four-Step Process - A multimedia (text, images and animations) introduction to the basic steps in synaptic transmission. (Multimedia Neuroscience Education Project)
    • The Yeast Pheromone Signal Transduction Pathway - Image map with links to relevant references. (Lab of David Thomas, NRC Biotechnology Research Institute, Canada)
• Biocarta Pathways- Cell Signaling
• Sigma Apoptosis Brochure
• Nature Journal of a Signaling Gateway.
  • "This Gateway represents a unique collaboration between academia and scientific publishing and is designed to facilitate navigation of the complex world of research into cellular signaling. Information and data presented here are freely available to all. "
  • Molecule Database

PubMed

Articles

Review Articles

Search NLM PubMed Database

Articles "cell+signal" | last 90 days | last 1 year | last 2 years | last 5 years | all articles |

Research Labs

Web Links

OMIM

The Online Mendelian Inheritence in Man (OMIM) database contains molecular references. The list below represents only a selected few of the entries, to see all related entries use the search feature below. OMIM Database

Search OMIM Database with "steroid hormone"

Related Topics

receptors, plasma membrane, tyrosine kinase, steroid receptor, transcription factors, kinase cascade, hormones, protein growth factors, cAMP, cGMP

Lecture Slide Text

Note that the text without the slide context and associated images may not make sense and is insufficient to understand all key issues.