This laboratory is an introduction to cell biology methods and historic background to cell biology discoveries. This laboratory page and textbook alone contain enough
information as an introduction to the subject for this level of study. If you are interested in further reading, I have also included below links to
more detailed textbooks and websites with further information and images. Please note this additional information is not necessarily examinable, but may be useful if
you have not previously studied biology.
Understand historic background of cell biology.
Understand common microscopic methods in looking at cells.
Brief understanding of the applications of these microscopic methods.
Brief understanding of the technolgy behind methods.
Page Links: Introduction History | Microscopy | Other Resources | NLM Online Textbooks | Search PubMed | Search Online Textbooks | Search Online Mendelian Inheritence in Man |
Todays class will begin by constructing timelines of cell biology history using a number of online resources.
Start by looking at some reviews of key discoveries as viewed by scientists writing for the Journal of Cell Biology (JCB). These papers look at the last 50 years of cell biology and are a selection of a few key research findings and researchers.
Journal of Cell Biology From The Archive
Divide into groups of 3 students and select one of the papers. You will then spend 20 minutes reading the paper and summarising the topic.
You group will then give a brief 5 minute description of the finding and where it fits in the timeline of cell biology.
Alternatively you can choose to look at the relationship of Nobel Awards to cell biology by constructing a timeline of awards and key findings.
The Nobel Prize in Physiology or Medicine - Laureates
Finally look at the recent genetic revolution Genome Timeline
Molecular Biology of the Cell - Looking at the Structure of Cells in the Microscope
Links:
History History of Microscopy
Scanning Electron Microscopy The Early History and Development of The Scanning Electron Microscope
Basic Concepts in Optical Microscopy
Journal Microscopy Today
Light Microscope Images UWA Blue Histology
Electron Microscope Images Dennis Kunkel's Microscopy
Cellular Imaging Microscopy & Imaging Resources on the WWW > K-12 Educational Resources
WWW Virtual Library: Microscopy
Museum of Microscopy - This site looks at the different forms of microscopy giving a brief description of each technique.
NCBI
MBoC | Publisher (Garland) MBoC
Search The Cell - "Microscopy Methods"
| "Cell Methods"
NCBI The Cell | Publisher
(Sinauer) The Cell
Search The Cell - "Cell Methods"
NCBI The Cell |
4th ed.
Lodish, Harvey; Berk, Arnold; Zipursky, S. Lawrence; Matsudaira, Paul; Baltimore, David; Darnell, James E.
New York: W. H. Freeman & Co.; c2000.
Search The Cell - "Cell Methods"
NCBI A search of NCBI PubMed MEDLINE database.
"MEDLINE is the NLM's premier bibliographic database covering the fields of medicine, nursing, dentistry, veterinary medicine, the health care system, and the preclinical sciences." (NCBI)
Searching with nearly any term will result in a large number of results that can be made more specific by either:
1. Using "Preview/Index" option to carry out an additional search and then combining with your first result. (#1 AND #2)
or
2. Using "Limits" option to set limits on your search results. (review, years, english, etc)
Searching the library with a term will show results from each textbook that can then be opened on a new page.
"The Bookshelf is a growing collection of biomedical books that can be searched directly by typing a concept" (NCBI)
NCBI OMIM "This database is a catalog of human genes and genetic disorders authored and edited by Dr. Victor A. McKusick and his colleagues at Johns Hopkins and elsewhere, and developed for the World Wide Web by NCBI, the National Center for Biotechnology Information. The database contains textual information and references. It also contains copious links to MEDLINE and sequence records in the Entrez system, and links to additional related resources at NCBI and elsewhere."
Different databases can be selected from the pulldown menu.
Selected option "Entrez" shows the results from searching all the different NCBI databases simultaneously.
NCBI "Established in 1988 as a national resource for molecular biology information, NCBI creates public databases, conducts research in computational biology, develops software tools for analyzing genome data, and disseminates biomedical information - all for the better understanding of molecular processes affecting human health and disease"
This allows a Search of NIH Medlineplus Medical Dictionary. Type the word that you would like to find. If unsure of spelling, type the first few letters, followed by an asterisk(*).
History History of Microscopy
Scanning Electron Microscopy The Early History and Development of The Scanning Electron Microscope
Basic Concepts in Optical Microscopy
Journal Microscopy Today
Light Microscope Images UWA Blue Histology
Electron Microscope Images Dennis Kunkel's Microscopy
Cellular Imaging Microscopy & Imaging Resources on the WWW > K-12 Educational Resources
WWW Virtual Library: Microscopy
Journal Cell Biology Education
Protocols Online Cell Biology
Molecular Expressions Optical Microscopy Resources on the Web |
microscopy, tissue culture, cell fractionation, histology, immunochemistry, protein separation,
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This Lab is an introduction to cell biology methods and a brief review of how historically these apply to key findings. Scientific Timeline
Please email Dr Mark Hill if you wish to make a comment about this current project.