This page introduces methods for glutamate cytotoxicity and links to relevant resources and papers.
We have been looking at inducing cell death in cultured adherant neuronal cells using glutamate excitotoxicity. There is a huge variety of techniques/analysis and applications used by different Labs.
Note also that many links on this page are to external internet resources.
Schubert D, Piasecki D. Oxidative glutamate toxicity can be a component of the excitotoxicity cascade. J Neurosci. 2001 Oct 1;21(19):7455-62.
Nishizawa Y. Glutamate release and neuronal damage in ischemia. Life Sci. 2001 Jun 15;69(4):369-81. Review.
Pin JP, Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 1995 Jan;34(1):1-26. Review.
Pin JP, Duvoisin R. mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons. Eur J Neurosci. 1999 Feb;11(2):663-72
Abe H, Tateyama M, Kubo Y.Functional identification of Gd3+ binding site of metabotropic glutamate receptor 1alpha. FEBS Lett. 2003 Jun 19;545(2-3):233-8.
These commercial links are for educational purposes only and do not reflect endorsement of a specific product.
Cat# G1251 L-Glutamic acid
Synonyms: (S)-2-Aminoglutaric acid, (S)-2-Aminopentanedioic acid, Glu
Molecular Weight: 147.13 CAS Number: 56-86-0
Biochem/physiol Actions: An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
Literature: Pin, J.-P., Dulvoisin, R., Neuropharmacology 34, 1 (1995)
Link to pruduct Information Sheet PDF: G1251 - Product Information Sheet (26kb)
There are many different methods for inducing programmed cell death in neurons and other cells. This page covers only those intended for use in our Lab.
Please email Dr Mark Hill if you wish to make a comment about this current project.