A specialized cytoplasmic structure formed for the degradation of proteins within the cell. It forms a large "barrel-like" protein complex, within which active proteolytic sites degrade proteins that have been "tagged" for destruction.
The "tagging" of protein is by the addition of ubiquitin (ubiquitination) which is the signal recognised by the proteosome.
Example: In cell cycle, degradation of cyclins in mitosis.
Molecular Biology of the Cell (4th ed.)
Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Raff, Martin; Roberts, Keith; Walter, Peter
New York: Garland Publishing. (c2002)
Molecular Cell Biology (4th ed.)
Lodish, Harvey; Berk, Arnold; Zipursky, S. Lawrence; Matsudaira, Paul; Baltimore, David; Darnell, James E.
New York: W. H. Freeman & Co. (c2000)
The Cell- A Molecular Approach (2nd ed.)
Cooper, Geoffrey M. Sunderland (MA): Sinauer Associates, Inc (c2000)
Cell Biology Site- This is a very large Map and can be view at several levels.
Medicine - module developed to support new medical curriculum
Science - module developed to support ANAT3231 course
About- Describes how the project website was designed
Lab Methods - some current Lab methods
Methods - brief description of cell biology methods
History - timeline of key discoveries
Glossary - list of terms and acronyms
Links - list of key internet links
Library- list of resource, including online textbooks, used in generating
information on this site.
Questions- start with a question about Cell Biology. Problems- start with
a problem in Cell Biology.
This Cell Biology Project began in 1997 and has been recently updated in 2003 as part of an ITET4 Fellowship.
Please email Dr Mark Hill if you wish to make a comment about this current project.